Technology Process of (S)-N-(2-(4-methylpiperazin-1-yl)-4-(trifluoromethoxy)-benzyl)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine
There total 5 articles about (S)-N-(2-(4-methylpiperazin-1-yl)-4-(trifluoromethoxy)-benzyl)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / acetonitrile / 0.5 h / Inert atmosphere
1.2: 16 h / 95 °C / Inert atmosphere
1.3: Inert atmosphere
2.1: sodium periodate; osmium(VIII) oxide / water; acetone; tert-butyl alcohol / 16 h / 0 - 20 °C
3.1: toluene-4-sulfonic acid / benzene / 8 h / 20 °C / Reflux
4.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.33 h / Inert atmosphere
4.2: 8 h / 90 °C / Inert atmosphere
5.1: hydrogenchloride / tetrahydrofuran; water / 0.5 h / 20 °C
6.1: acetic acid / N,N-dimethyl-formamide / 20 °C
6.2: 24 h
With
hydrogenchloride; sodium periodate; osmium(VIII) oxide; caesium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/jm1010644
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride / tetrahydrofuran; water / 0.5 h / 20 °C
2.1: acetic acid / N,N-dimethyl-formamide / 20 °C
2.2: 24 h
With
hydrogenchloride; acetic acid;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm1010644
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium periodate; osmium(VIII) oxide / water; acetone; tert-butyl alcohol / 16 h / 0 - 20 °C
2.1: toluene-4-sulfonic acid / benzene / 8 h / 20 °C / Reflux
3.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.33 h / Inert atmosphere
3.2: 8 h / 90 °C / Inert atmosphere
4.1: hydrogenchloride / tetrahydrofuran; water / 0.5 h / 20 °C
5.1: acetic acid / N,N-dimethyl-formamide / 20 °C
5.2: 24 h
With
hydrogenchloride; sodium periodate; osmium(VIII) oxide; caesium carbonate; toluene-4-sulfonic acid; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; benzene;
DOI:10.1021/jm1010644
