methyl all-E 3-methoxy-4-methyl-7-phenylhepta-2,4,6-trienoate

Base Information

• Chemical Name: methyl all-E 3-methoxy-4-methyl-7-phenylhepta-2,4,6-trienoate
• CAS No.: 910131-68-9
• Molecular Formula: C₁₆H₁₈O₃
• Molecular Weight: 258.317
• Mol file: 910131-68-9.mol

Synonyms:methyl all-E 3-methoxy-4-methyl-7-phenylhepta-2,4,6-trienoate

Chemical Property of methyl all-E 3-methoxy-4-methyl-7-phenylhepta-2,4,6-trienoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl all-E 3-methoxy-4-methyl-7-phenylhepta-2,4,6-trienoate

There total 5 articles about methyl all-E 3-methoxy-4-methyl-7-phenylhepta-2,4,6-trienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 5,6-dihydro-4-methoxy-5-methyl-6-E-(2-phenylethenyl)-2H-pyran-2-one → methyl all-E 3-methoxy-4-methyl-7-phenylhepta-2,4,6-trienoate (910131-68-9) + methyl (5SR)-hydroxy-3-methoxy-(4RS)-methyl-7-phenyl-E-2,E-6-heptadienoate + methyl (5RS)-hydroxy-3-methoxy-(4RS)-methyl-7-phenyl-E-2,E-6-heptadienoate

Guidance literature:

5,6-dihydro-4-methoxy-5-methyl-6-E-(2-phenylethenyl)-2H-pyran-2-one; With potassium hydroxide; water; for 1.5h; Heating;

diazomethane; In diethyl ether; at 0 ℃; Further stages. Title compound not separated from byproducts.;

DOI:10.1039/b603433k

Reference yield:

methyl propanoyl acetate (30414-53-0) → methyl all-E 3-methoxy-4-methyl-7-phenylhepta-2,4,6-trienoate (910131-68-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH, n-BuLi / 1.) THF, 0 deg C

2: K₂CO₃ / acetone / Heating

3: 1.) KOH, H₂O

With potassium hydroxide; n-butyllithium; water; sodium hydride; potassium carbonate; In acetone;

DOI:10.1016/S0040-4039(00)60700-1

Reference yield:

3-phenyl-propenal (104-55-2) → methyl all-E 3-methoxy-4-methyl-7-phenylhepta-2,4,6-trienoate (910131-68-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH, n-BuLi / 1.) THF, 0 deg C

2: K₂CO₃ / acetone / Heating

3: 1.) KOH, H₂O

With potassium hydroxide; n-butyllithium; water; sodium hydride; potassium carbonate; In acetone;

DOI:10.1016/S0040-4039(00)60700-1

upstream raw materials:

diazomethane

methyl propanoyl acetate

3-phenyl-propenal