N-p-Chlorbenzyl-N-benzylhydroxylamin

Base Information

• Chemical Name: N-p-Chlorbenzyl-N-benzylhydroxylamin
• CAS No.: 55648-94-7
• Molecular Formula: C₁₄H₁₄ClNO
• Molecular Weight: 247.724
• Mol file: 55648-94-7.mol

Synonyms:N-p-Chlorbenzyl-N-benzylhydroxylamin

Chemical Property of N-p-Chlorbenzyl-N-benzylhydroxylamin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-p-Chlorbenzyl-N-benzylhydroxylamin

There total 4 articles about N-p-Chlorbenzyl-N-benzylhydroxylamin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzylhydroxylamine hydrochloride (29601-98-7) + 4-chlorobenzaldehyde (104-88-1) → N-p-Chlorbenzyl-N-benzylhydroxylamin (55648-94-7)

Guidance literature:

N-benzylhydroxylamine hydrochloride; 4-chlorobenzaldehyde; With sodium hydrogencarbonate; magnesium sulfate; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

With hydrogenchloride; sodium cyanoborohydride; In tetrahydrofuran; methanol; diethyl ether; water; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201809003

Reference yield:

N-(benzylidene)-4-chlorobenzylamine N-oxide (55606-33-2) → N-p-Chlorbenzyl-N-benzylhydroxylamin (55648-94-7)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In tetrahydrofuran; methanol; diethyl ether; at 20 ℃; for 1h;

DOI:10.1002/anie.201902642

Reference yield:

N-(4-chlorobenzyl)hydroxylamine hydrochloride → N-p-Chlorbenzyl-N-benzylhydroxylamin (55648-94-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; magnesium sulfate / dichloromethane / 12 h / 20 °C

2: sodium cyanoborohydride; hydrogenchloride / tetrahydrofuran; diethyl ether; methanol / 1 h / 20 °C

With hydrogenchloride; sodium cyanoborohydride; sodium hydrogencarbonate; magnesium sulfate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;

DOI:10.1002/anie.201902642

upstream raw materials:

N-benzylhydroxylamine hydrochloride

4-chlorobenzaldehyde

N-(benzylidene)-4-chlorobenzylamine N-oxide