(1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-PHENYL-AMINE

Base Information

• Chemical Name: (1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-PHENYL-AMINE
• CAS No.: 14704-61-1
• Molecular Formula: C₁₅H₁₅N₃
• Molecular Weight: 237.304
• Mol file: 14704-61-1.mol

Synonyms:N-((1-methyl-1H-benzimidazol-2-yl)methyl) aniline

Chemical Property of (1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-PHENYL-AMINE

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

(1-Methyl-1H-benzoimidazol-2-ylmethyl)-phenyl-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of (1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-PHENYL-AMINE

There total 4 articles about (1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-PHENYL-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-chloromethyl-1-methyl-1H-benzimidazole (4760-35-4) + aniline (62-53-3) → N-((1-methyl-1H-benzimidazol-2-yl)methyl) aniline (14704-61-1)

Guidance literature:

2-chloromethyl-1-methyl-1H-benzimidazole; aniline; With potassium iodide; In ethanol; Reflux; Inert atmosphere;

With potassium hydroxide; In ethanol; for 4h; Reflux; Inert atmosphere;

DOI:10.1039/c8dt05001e

Reference yield:

2-(Hydroxymethyl)benzimidazole (4856-97-7) → N-((1-methyl-1H-benzimidazol-2-yl)methyl) aniline (14704-61-1)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol; aqueous NaOH

2: SOCl₂

With methanol; sodium hydroxide; thionyl chloride;

Reference yield:

(1-methyl-1H-benzimidazol-2-yl)methanol (7467-35-8) → N-((1-methyl-1H-benzimidazol-2-yl)methyl) aniline (14704-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

With thionyl chloride;

upstream raw materials:

2-chloromethyl-1-methyl-1H-benzimidazole

aniline

2-(Hydroxymethyl)benzimidazole

(1-methyl-1H-benzimidazol-2-yl)methanol

Refernces