7467-35-8

Basic information

• Product Name: (1-METHYL-1H-BENZOIMIDAZOL-2-YL)-METHANOL
• Synonyms: 1H-Benzimidazole-2-methanol,1-methyl-(9CI);(1-methyl-1H-benzimidazol-2-yl)methanol(SALTDATA: FREE);(1-methyl-2-benzimidazolyl)methanol;(1-methylbenzimidazol-2-yl)methanol;(1-methyl-1H-benzo[d]imidazol-2-yl)methanol
• CAS NO: 7467-35-8
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.19
• Product Categories: BENZIMIDAZOLE
• Mol File: 7467-35-8.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 351.7 °C at 760 mmHg
• Flash Point: 166.5 °C
• Appearance: /
• Density: 1.22 g/cm³
• Vapor Pressure: 1.5E-05mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (1-METHYL-1H-BENZOIMIDAZOL-2-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (1-METHYL-1H-BENZOIMIDAZOL-2-YL)-METHANOL(7467-35-8)
• EPA Substance Registry System: (1-METHYL-1H-BENZOIMIDAZOL-2-YL)-METHANOL(7467-35-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 7467-35-8(Hazardous Substances Data)

Usage

Uses

1-Methyl-1H-benzimidazole-2-methanol acts as a reagent in the synthesis, structure-activity relationship, antibacterial and antifungal activities of benzimidazoles. Design, synthesis and computational validation of novel benzimidazole/indole-based PPARα and PPARβ partial agonists.

InChI:InChI=1/C9H10N2O/c1-11-8-5-3-2-4-7(8)10-9(11)6-12/h2-5,12H,6H2,1H3

Upstream product

• 1632-83-3 1-Methylbenzimidazole 
• 4856-97-7 2-(Hydroxymethyl)benzimidazole 
• 74-88-4 methyl iodide 
• 3012-80-4 1-methyl-2-formyl-1H-benzimidazole 
• 50-00-0 formaldehyd 
• 2849-93-6 2-benzimidazolecarboxylic acid 
• 35342-97-3 ethyl 1-methyl-1H-benzo[d]imidazole-2-carboxylate 
• 1865-09-4 ethyl 1H-benzimidazole-2-carboxylate 
• 74-83-9 methyl bromide 
• 79-14-1 glycolic Acid 
• 25148-68-9 N-methylbenzene-1,2-diamine dihydrochloride 
• 95-54-5 1,2-diamino-benzene 
• 64266-27-9 3-(2-Hydroxymethyl-benzoimidazol-1-yl)-propionitrile 
• 449796-13-8 N-acetoxy-2-(acetoxymethyl)benzimidazole 

Downstream Products

• 1357162-25-4 C₂₀H₁₈N₂O₃ 
• 1357162-33-4 C₂₀H₁₈N₂O₃ 
• 109029-13-2 4-[(1-methyl-1H-benzimidazol-2-yl)methoxy]aniline 
• 1413429-75-0 diethyl {4-[(1-methyl-1H-benzimidazol-2-yl)methoxy]benzylidene}propanedioate 
• 1413429-76-1 diethyl {4-[(1-methyl-1H-benzimidazol2-yl)methoxy]benzyl}propanedioate 
• 1413429-73-8 methyl 2-bromo-3-{4-[(1-methyl-1H-benzimidazol-2-yl)methoxy]phenyl}propanoate 
• 1413429-74-9 5-{4-[(1-methyl-1H-benzimidazol-2-yl)methoxy]benzylidene}-1,3-thiazolidine-2,4-dione 
• 118001-75-5 4-<(1-methyl-2-1H-benzimidazolyl)methoxy>benzaldehyde 
• 109029-43-8 C₁₅H₁₃N₃O₃ 
• 59871-40-8 2-benzyl-1-methyl-1H-benzo[d]imidazole 
• 101092-40-4 (E)-1-methyl-2-((2-phenylhydrazineylidene)methyl)-1H-benzo[d]imidazole 

Relevant articles and documents

COMPOUNDS AS GLP-1R AGONISTS

The present application provides compounds that may be used as a glucagon-like peptide-1 receptors (GLP-1R) agonist, or stereoisomers, tautomers, or pharmaceutically acceptable salts of any of the foregoing. Also provided are pharmaceutical compositions containing such compounds, or stereoisomers, tautomers, or pharmaceutically acceptable salts of any of the foregoing. Methods of prepare these compounds and compositions and method of using them to treat or present a disease or a condition mediated by GLP-1R.

ADENOSINE RECEPTOR BINDING COMPOUNDS

The present invention relates to pharmaceutical compounds and compositions of Formula (I) and methods of treatment using the compounds and compositions, especially for the treatment and/or prevention of a proliferation disorder, such as cancer. Compounds of Formula (I) as further described herein are shown modulators of the adenosine A2A receptor and exhibit antiproliferative activity. Accordingly, these compounds are useful to treat proliferative disorders such as cancer, and other adenosine receptor-related conditions including an inflammatory disease, renal disease, diabetes, vascular disease, lung disease, or an autoimmune disease.

Cobalt(II) complexes based on (1-methyl-1H-benzo[d]imidazol-2-yl) methanol derivative: synthesis, crystal structure, spectroscopy, DFT calculations, and antioxidant activity

In this paper, we present a combined experimental and computational study of two new cobalt(II) complexes as [Co(Hmbm)2(OAc)2] and [Co(Hmbm)2(H2O)2]Cl2 (Hmbm = (1-methyl-1H-benzo[d]imidazol-2-yl)methanol). Both complexes were characterized by FT-IR and UV–vis spectroscopy, elemental analysis, and single-crystal X-ray crystallography. The molecular geometries, electronic transitions, and vibrational frequencies of the two complexes and the ligand (Hmbm) in the ground state have been calculated using global hybrid (B3LYP) and range-separated hybrid (CAM-B3LYP) density functional. Qualitative description of excited states and charge transfer character of electronic transitions states were carried out by plotting the Natural Transition Orbitals (NTOs) for main states, and were assigned to LMCT. The ligand and its Co(II) complexes have been evaluated for their potential as DPPH radical scavengers.