10-chloro-N-cyclohexyl-2-(3,4-dimethylphenyl)-3-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-1-carboxamide

Base Information

Chemical Name:10-chloro-N-cyclohexyl-2-(3,4-dimethylphenyl)-3-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-1-carboxamide
CAS No.:1381804-06-3
Molecular Formula:C₂₆H₂₈ClN₃O₂
Molecular Weight:449.98
Hs Code.:

Synonyms:10-chloro-N-cyclohexyl-2-(3,4-dimethylphenyl)-3-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-1-carboxamide

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Chemical Property of 10-chloro-N-cyclohexyl-2-(3,4-dimethylphenyl)-3-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-1-carboxamide

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Technology Process of 10-chloro-N-cyclohexyl-2-(3,4-dimethylphenyl)-3-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-1-carboxamide

There total 3 articles about 10-chloro-N-cyclohexyl-2-(3,4-dimethylphenyl)-3-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 931-53-3
Cyclohexyl isocyanide

: 1381803-63-9
2-(3-chloro-2-formyl-1H-indol-1-yl)acetic acid

: 95-64-7
4-amino-o-xylene

: 1381804-06-3
10-chloro-N-cyclohexyl-2-(3,4-dimethylphenyl)-3-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-1-carboxamide

Guidance literature:: In methanol; at 40 ℃; for 4h;
DOI:10.1016/j.tetlet.2012.04.090

Reference yield:

: 1381803-57-1
methyl 2-(3-chloro-2-formyl-1H-indol-1-yl)acetate

: 1381804-06-3
10-chloro-N-cyclohexyl-2-(3,4-dimethylphenyl)-3-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol; water / 4 h / 20 °C

1.2: pH 3 - 4

2.1: methanol / 4 h / 40 °C

With sodium hydroxide; In methanol; water; 2.1: Ugi reaction;
DOI:10.1016/j.tetlet.2012.04.090

Reference yield:

: 110912-15-7
3-chloro-1H-indole-2-carboxaldehyde

: 1381804-06-3
10-chloro-N-cyclohexyl-2-(3,4-dimethylphenyl)-3-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 6 h / Reflux

2.1: sodium hydroxide / methanol; water / 4 h / 20 °C

2.2: pH 3 - 4

3.1: methanol / 4 h / 40 °C

With potassium carbonate; sodium hydroxide; In methanol; water; acetonitrile; 3.1: Ugi reaction;
DOI:10.1016/j.tetlet.2012.04.090