ethyl 2-(4-((2-(4-(3-(3-chlorophenyl)ureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate

Base Information

Chemical Name:ethyl 2-(4-((2-(4-(3-(3-chlorophenyl)ureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate
CAS No.:1387637-12-8
Molecular Formula:C₂₅H₂₈ClN₅O₃S
Molecular Weight:514.048
Hs Code.:

Synonyms:ethyl 2-(4-((2-(4-(3-(3-chlorophenyl)ureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate

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Chemical Property of ethyl 2-(4-((2-(4-(3-(3-chlorophenyl)ureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate

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Technology Process of ethyl 2-(4-((2-(4-(3-(3-chlorophenyl)ureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate

There total 6 articles about ethyl 2-(4-((2-(4-(3-(3-chlorophenyl)ureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.1%

: 1387637-06-0
1-(3-chlorophenyl)-3-(4-(4-(piperazin-1-ylmethyl)thiazol-2-yl)phenyl)urea

: 105-39-5
chloroacetic acid ethyl ester

: 1387637-12-8
ethyl 2-(4-((2-(4-(3-(3-chlorophenyl)ureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate

Guidance literature:: With potassium carbonate; sodium iodide; In ethanol; at 50 ℃; for 2h;
DOI:10.3390/molecules18032904

Reference yield:

: 1041552-69-5
4-(3-(3-chlorophenyl)ureido)benzothioamide

: 1387637-12-8
ethyl 2-(4-((2-(4-(3-(3-chlorophenyl)ureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 7 h / 50 °C

2: ethanol / 2 h / 20 °C

3: potassium carbonate; sodium iodide / ethanol / 2 h / 50 °C

With potassium carbonate; sodium iodide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.cclet.2012.06.009

Reference yield:

: 40465-45-0
p-cyanophenyl isocyanate

: 1387637-12-8
ethyl 2-(4-((2-(4-(3-(3-chlorophenyl)ureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 1 h / 20 °C

2: sodium hydrogensulfide; magnesium chloride / N,N-dimethyl-formamide

3: tetrahydrofuran / 7 h / 50 °C

4: ethanol / 2 h / 20 °C

5: potassium carbonate; sodium iodide / ethanol / 2 h / 50 °C

With sodium hydrogensulfide; potassium carbonate; sodium iodide; magnesium chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.cclet.2012.06.009