(1R,2R,4aS,7S,8S,8aR)-2-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-7-((dimethyl(phenyl)silyl)methyl)-8-((4-methoxybenzyl)oxy)-1,2,4a,7,8,8a-hexahydronaphthalen-1-ol

Base Information

Chemical Name:(1R,2R,4aS,7S,8S,8aR)-2-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-7-((dimethyl(phenyl)silyl)methyl)-8-((4-methoxybenzyl)oxy)-1,2,4a,7,8,8a-hexahydronaphthalen-1-ol
CAS No.:1006380-59-1
Molecular Formula:C₄₅H₅₆O₄Si₂
Molecular Weight:717.108
Hs Code.:

(1R,2R,4aS,7S,8S,8aR)-2-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-7-((dimethyl(phenyl)silyl)methyl)-8-((4-methoxybenzyl)oxy)-1,2,4a,7,8,8a-hexahydronaphthalen-1-ol

Synonyms:(1R,2R,4aS,7S,8S,8aR)-2-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-7-((dimethyl(phenyl)silyl)methyl)-8-((4-methoxybenzyl)oxy)-1,2,4a,7,8,8a-hexahydronaphthalen-1-ol

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Chemical Property of (1R,2R,4aS,7S,8S,8aR)-2-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-7-((dimethyl(phenyl)silyl)methyl)-8-((4-methoxybenzyl)oxy)-1,2,4a,7,8,8a-hexahydronaphthalen-1-ol

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Technology Process of (1R,2R,4aS,7S,8S,8aR)-2-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-7-((dimethyl(phenyl)silyl)methyl)-8-((4-methoxybenzyl)oxy)-1,2,4a,7,8,8a-hexahydronaphthalen-1-ol

There total 13 articles about (1R,2R,4aS,7S,8S,8aR)-2-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-7-((dimethyl(phenyl)silyl)methyl)-8-((4-methoxybenzyl)oxy)-1,2,4a,7,8,8a-hexahydronaphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1006380-56-8
(1R,2R)-2-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-1-((1R,2S,5S,6S)-5-((dimethyl(phenyl)silyl)methyl)-6-((4-methoxybenzyl)oxy)-2-vinylcyclohex-3-en-1-yl)but-3-en-1-ol

: 1006380-59-1
(1R,2R,4aS,7S,8S,8aR)-2-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-7-((dimethyl(phenyl)silyl)methyl)-8-((4-methoxybenzyl)oxy)-1,2,4a,7,8,8a-hexahydronaphthalen-1-ol

Guidance literature:: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; at 50 ℃; for 2h;
DOI:10.1021/ol7027338

Reference yield:

: 1006380-51-3
((1R,2S,5S,6S)-5-((dimethyl(phenyl)silyl)methyl)-6-((4-methoxybenzyl)oxy)-2-vinylcyclohex-3-en-1-yl)methanol

: 1006380-59-1
(1R,2R,4aS,7S,8S,8aR)-2-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-7-((dimethyl(phenyl)silyl)methyl)-8-((4-methoxybenzyl)oxy)-1,2,4a,7,8,8a-hexahydronaphthalen-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0.5 h / Inert atmosphere

2: chromium dichloride / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 2 h / 50 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; chromium dichloride; sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; N,N-dimethyl-formamide; toluene; 2: Hiyama-Nozaki-Kishi reaction;
DOI:10.1002/chem.201200257

Reference yield:

: 1006380-52-4
(1S,2S,5S,6S)-5-((dimethyl(phenyl)silyl)methyl)-6-((4-methoxybenzyl)oxy)-2-vinylcyclohex-3-enecarbaldehyde

: 1006380-59-1
(1R,2R,4aS,7S,8S,8aR)-2-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-7-((dimethyl(phenyl)silyl)methyl)-8-((4-methoxybenzyl)oxy)-1,2,4a,7,8,8a-hexahydronaphthalen-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: chromium dichloride / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 2 h / 50 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; chromium dichloride; In N,N-dimethyl-formamide; toluene; 1: Hiyama-Nozaki-Kishi reaction;
DOI:10.1002/chem.201200257