((1R,2S,5S,6S)-5-((dimethyl(phenyl)silyl)methyl)-6-((4-methoxybenzyl)oxy)-2-vinylcyclohex-3-en-1-yl)methanol

Base Information

Chemical Name:((1R,2S,5S,6S)-5-((dimethyl(phenyl)silyl)methyl)-6-((4-methoxybenzyl)oxy)-2-vinylcyclohex-3-en-1-yl)methanol
CAS No.:1006380-51-3
Molecular Formula:C₂₆H₃₄O₃Si
Molecular Weight:422.64
Hs Code.:

Synonyms:((1R,2S,5S,6S)-5-((dimethyl(phenyl)silyl)methyl)-6-((4-methoxybenzyl)oxy)-2-vinylcyclohex-3-en-1-yl)methanol

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Chemical Property of ((1R,2S,5S,6S)-5-((dimethyl(phenyl)silyl)methyl)-6-((4-methoxybenzyl)oxy)-2-vinylcyclohex-3-en-1-yl)methanol

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Technology Process of ((1R,2S,5S,6S)-5-((dimethyl(phenyl)silyl)methyl)-6-((4-methoxybenzyl)oxy)-2-vinylcyclohex-3-en-1-yl)methanol

There total 13 articles about ((1R,2S,5S,6S)-5-((dimethyl(phenyl)silyl)methyl)-6-((4-methoxybenzyl)oxy)-2-vinylcyclohex-3-en-1-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1006380-50-2
(((2S,4aR,5S,8S,8aS)-2-(4-methoxyphenyl)-5-vinyl-4a,5,8,8a-tetrahydro-4H-benzo[d][1,3]dioxin-8-yl)methyl)dimethyl(phenyl)silane

: 1006380-51-3
((1R,2S,5S,6S)-5-((dimethyl(phenyl)silyl)methyl)-6-((4-methoxybenzyl)oxy)-2-vinylcyclohex-3-en-1-yl)methanol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at 0 ℃; for 4h;
DOI:10.1021/ol7027338

Reference yield: 78.0%

: (((2S,4aR,5S,8S,8aS)-2-(4-methoxyphenyl)-5-vinyl-4a,5,8,8a-tetrahydro-4H-benzo[d][1,3]dioxin-8-yl)methyl)dimethyl(phenyl)silane

: 1006380-51-3
((1R,2S,5S,6S)-5-((dimethyl(phenyl)silyl)methyl)-6-((4-methoxybenzyl)oxy)-2-vinylcyclohex-3-en-1-yl)methanol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at 0 ℃; for 4h; Inert atmosphere;
DOI:10.1002/chem.201200257

Reference yield:

: 1006380-49-9
(R)-1-((2S,4aR,5S,8S,8aS)-8-((dimethyl(phenyl)silyl)methyl)-2-(4-methoxyphenyl)-4a,5,8,8a-tetrahydro-4H-benzo[d][1,3]dioxin-5-yl)-2-(trimethylsilyl)ethanol

: 1006380-51-3
((1R,2S,5S,6S)-5-((dimethyl(phenyl)silyl)methyl)-6-((4-methoxybenzyl)oxy)-2-vinylcyclohex-3-en-1-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide; toluene / 60 °C / Inert atmosphere

2: diisobutylaluminium hydride / dichloromethane; toluene / 4 h / 0 °C / Inert atmosphere

With sodium hexamethyldisilazane; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/chem.201200257