3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)-5,6-dihydro-4H-1,2,4-oxadiazine

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Chemical Name:3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)-5,6-dihydro-4H-1,2,4-oxadiazine
CAS No.:1383852-31-0
Molecular Formula:C₁₇H₁₅BrN₄O₂
Molecular Weight:387.236
Hs Code.:

Synonyms:3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)-5,6-dihydro-4H-1,2,4-oxadiazine

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Chemical Property of 3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)-5,6-dihydro-4H-1,2,4-oxadiazine

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Technology Process of 3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)-5,6-dihydro-4H-1,2,4-oxadiazine

There total 5 articles about 3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)-5,6-dihydro-4H-1,2,4-oxadiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1383852-30-9
3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)-4-(2-chloroethyl)-1,2,4-oxadiazol-5(4H)-one

: 1383852-31-0
3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)-5,6-dihydro-4H-1,2,4-oxadiazine

Guidance literature:: With sodium hydroxide; In ethanol; for 1h; Reflux;

Reference yield:

: 22282-99-1
4-bromo-2-methylpyridine

: 1383852-31-0
3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)-5,6-dihydro-4H-1,2,4-oxadiazine

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / 20 °C

2.1: hydroxylamine hydrochloride; sodium hydroxide / methanol; water / 2 h / Reflux

3.1: trifluoroacetic anhydride / 1,2-dimethoxyethane / 0.67 h / 20 °C / Inert atmosphere

3.2: 6.5 h / 0 °C / Inert atmosphere

3.3: 16 h / 70 °C / Inert atmosphere

4.1: trichlorophosphate / 1,2-dimethoxyethane / 3 h / 20 °C / Inert atmosphere

4.2: pH 7 / Inert atmosphere

5.1: hydroxylamine hydrochloride / ethanol; water / 2 h / Reflux

6.1: acetic anhydride / 24 h / 140 °C

7.1: hydroxylamine / dimethyl sulfoxide / 3 h / 130 °C / microwave

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 1 h / Reflux

9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ISOPROPYLAMIDE / 20 h / 100 °C

10.1: sodium hydroxide / ethanol / 1 h / Reflux

With hydroxylamine hydrochloride; hydroxylamine; acetic anhydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic anhydride; sodium hydroxide; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; ISOPROPYLAMIDE; water; dimethyl sulfoxide;

Reference yield:

: 1383852-24-1
5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine

: 1383852-31-0
3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)-5,6-dihydro-4H-1,2,4-oxadiazine

Guidance literature:: Multi-step reaction with 7 steps

1.1: trichlorophosphate / 1,2-dimethoxyethane / 3 h / 20 °C / Inert atmosphere

1.2: pH 7 / Inert atmosphere

2.1: hydroxylamine hydrochloride / ethanol; water / 2 h / Reflux

3.1: acetic anhydride / 24 h / 140 °C

4.1: hydroxylamine / dimethyl sulfoxide / 3 h / 130 °C / microwave

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 1 h / Reflux

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ISOPROPYLAMIDE / 20 h / 100 °C

7.1: sodium hydroxide / ethanol / 1 h / Reflux

With hydroxylamine hydrochloride; hydroxylamine; acetic anhydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; ISOPROPYLAMIDE; water; dimethyl sulfoxide;