(E)-3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)acrylaldehyde

Base Information

Chemical Name:(E)-3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)acrylaldehyde
CAS No.:1391989-90-4
Molecular Formula:C₁₇H₁₃BrN₂O₂
Molecular Weight:357.206
Hs Code.:

Synonyms:(E)-3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)acrylaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)acrylaldehyde

Chemical Property:

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Technology Process of (E)-3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)acrylaldehyde

There total 7 articles about (E)-3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)acrylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-N-(3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)allylidene)-N-methylmethanaminium chloride

: 1391989-90-4
(E)-3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)acrylaldehyde

Guidance literature:: With water; potassium hydrogencarbonate; In methanol; at 20 ℃; for 1h;

Reference yield:

: 1383852-22-9
2-(4-bromopyridin-2-yl)-1-(4-methoxyphenyl)ethanone

: 1391989-90-4
(E)-3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)acrylaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol / 48 h / 20 - 60 °C

2: triethylamine; trifluoroacetic anhydride / dichloromethane / 5.33 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 1 h / 175 °C

4: trichlorophosphate / 1,2-dichloro-ethane / 2.5 h / 0 - 65 °C / Inert atmosphere

5: water; potassium hydrogencarbonate / methanol / 1 h / 20 °C

With hydroxylamine hydrochloride; water; potassium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; trichlorophosphate; In methanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 22282-99-1
4-bromo-2-methylpyridine

: 1391989-90-4
(E)-3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)acrylaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 72 h / 0 - 20 °C

2: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol / 48 h / 20 - 60 °C

3: triethylamine; trifluoroacetic anhydride / dichloromethane / 5.33 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 1 h / 175 °C

5: trichlorophosphate / 1,2-dichloro-ethane / 2.5 h / 0 - 65 °C / Inert atmosphere

6: water; potassium hydrogencarbonate / methanol / 1 h / 20 °C

With hydroxylamine hydrochloride; water; potassium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane;