<3(2R,3R,4R),4R>-3-<4--N-methylamino>-3-hydroxy-5-methoxy-2-<(4-methoxyphenyl)methoxy>-1-oxopentyl>-4-(phenylmethyl)-2-oxazolidinone

Base Information

Chemical Name:<3(2R,3R,4R),4R>-3-<4--N-methylamino>-3-hydroxy-5-methoxy-2-<(4-methoxyphenyl)methoxy>-1-oxopentyl>-4-(phenylmethyl)-2-oxazolidinone
CAS No.:139462-28-5
Molecular Formula:C₃₃H₃₈N₂O₉
Molecular Weight:606.673
Hs Code.:

<3(2R,3R,4R),4R>-3-<4-<N-<(phenylmethoxy)carbonyl>-N-methylamino>-3-hydroxy-5-methoxy-2-<(4-methoxyphenyl)methoxy>-1-oxopentyl>-4-(phenylmethyl)-2-oxazolidinone

Synonyms:<3(2R,3R,4R),4R>-3-<4--N-methylamino>-3-hydroxy-5-methoxy-2-<(4-methoxyphenyl)methoxy>-1-oxopentyl>-4-(phenylmethyl)-2-oxazolidinone

Suppliers and Price of <3(2R,3R,4R),4R>-3-<4--N-methylamino>-3-hydroxy-5-methoxy-2-<(4-methoxyphenyl)methoxy>-1-oxopentyl>-4-(phenylmethyl)-2-oxazolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of <3(2R,3R,4R),4R>-3-<4--N-methylamino>-3-hydroxy-5-methoxy-2-<(4-methoxyphenyl)methoxy>-1-oxopentyl>-4-(phenylmethyl)-2-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of <3(2R,3R,4R),4R>-3-<4--N-methylamino>-3-hydroxy-5-methoxy-2-<(4-methoxyphenyl)methoxy>-1-oxopentyl>-4-(phenylmethyl)-2-oxazolidinone

There total 15 articles about <3(2R,3R,4R),4R>-3-<4--N-methylamino>-3-hydroxy-5-methoxy-2-<(4-methoxyphenyl)methoxy>-1-oxopentyl>-4-(phenylmethyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39608-31-6
N-(Benzyloxycarbonyl)sarcosine

: 139462-28-5
<3(2R,3R,4R),4R>-3-<4--N-methylamino>-3-hydroxy-5-methoxy-2-<(4-methoxyphenyl)methoxy>-1-oxopentyl>-4-(phenylmethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / diethyl ether / 1 h / 0 °C

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, a) -78 deg C, 15 min, b) 0 deg C, 30 min

3: 1.) TiCl₄, diisopropylethylamine, 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, 3 h, 2.) CH₂Cl₂, 25 deg C, 2 h

4: 93 percent / LiBH₄ / methanol; tetrahydrofuran / 0.67 h / 0 °C

5: 1.) oxalyl chloride, DMSO, 2.) diisopropylethylamine / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, -50 deg C, 1 h

6: 1.) Sn(OTf)2, Et₃N, 2.) TMEDA

With lithium borohydride; tin(II) trifluoromethanesulfonate; n-butyllithium; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; boron trifluoride diethyl etherate; titanium tetrachloride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/ja00050a024

Reference yield:

: 139462-22-9
<4S>-3-<2--N-Methylamino>-1-oxoethyl>-4-(phenylmethyl)-2-oxazolidinone

: 139462-28-5
<3(2R,3R,4R),4R>-3-<4--N-methylamino>-3-hydroxy-5-methoxy-2-<(4-methoxyphenyl)methoxy>-1-oxopentyl>-4-(phenylmethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) TiCl₄, diisopropylethylamine, 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, 3 h, 2.) CH₂Cl₂, 25 deg C, 2 h

2: 93 percent / LiBH₄ / methanol; tetrahydrofuran / 0.67 h / 0 °C

3: 1.) oxalyl chloride, DMSO, 2.) diisopropylethylamine / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, -50 deg C, 1 h

4: 1.) Sn(OTf)2, Et₃N, 2.) TMEDA

With lithium borohydride; tin(II) trifluoromethanesulfonate; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; boron trifluoride diethyl etherate; titanium tetrachloride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;
DOI:10.1021/ja00050a024

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 139462-28-5
<3(2R,3R,4R),4R>-3-<4--N-methylamino>-3-hydroxy-5-methoxy-2-<(4-methoxyphenyl)methoxy>-1-oxopentyl>-4-(phenylmethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 7 steps

1: NaOH / H₂O / 0.5 h / 25 °C

2: Et₃N / diethyl ether / 1 h / 0 °C

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, a) -78 deg C, 15 min, b) 0 deg C, 30 min

4: 1.) TiCl₄, diisopropylethylamine, 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, 3 h, 2.) CH₂Cl₂, 25 deg C, 2 h

5: 93 percent / LiBH₄ / methanol; tetrahydrofuran / 0.67 h / 0 °C

6: 1.) oxalyl chloride, DMSO, 2.) diisopropylethylamine / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, -50 deg C, 1 h

7: 1.) Sn(OTf)2, Et₃N, 2.) TMEDA

With sodium hydroxide; lithium borohydride; tin(II) trifluoromethanesulfonate; n-butyllithium; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; boron trifluoride diethyl etherate; titanium tetrachloride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1021/ja00050a024