[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid 4-benzyloxycarbonylmethyl-phenyl ester

Base Information

Chemical Name:[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid 4-benzyloxycarbonylmethyl-phenyl ester
CAS No.:335200-37-8
Molecular Formula:C₂₉H₃₄O₅Si
Molecular Weight:490.671
Hs Code.:

[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid 4-benzyloxycarbonylmethyl-phenyl ester

Synonyms:[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid 4-benzyloxycarbonylmethyl-phenyl ester

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Chemical Property of [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid 4-benzyloxycarbonylmethyl-phenyl ester

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Technology Process of [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid 4-benzyloxycarbonylmethyl-phenyl ester

There total 5 articles about [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid 4-benzyloxycarbonylmethyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 27727-37-3
benzyl p-hydroxyphenylacetate

: 114774-40-2
2-(4-((tert-butyldimethylsilyl)oxy)phenyl)acetic acid

: 335200-37-8
[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid 4-benzyloxycarbonylmethyl-phenyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1039/b008065i

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 335200-37-8
[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid 4-benzyloxycarbonylmethyl-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 16 °C / Heating

2: 76 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate; N,N-diisopropylethylamine / tetrahydrofuran / 2 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; acetonitrile;
DOI:10.1039/b008065i

Reference yield:

: 27727-37-3
benzyl p-hydroxyphenylacetate

: 335200-37-8
[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid 4-benzyloxycarbonylmethyl-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / imidazol / dimethylformamide / 4 h

2: 97 percent / H₂ / Pd/C / methanol; ethyl acetate / 4 h

3: 76 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate; N,N-diisopropylethylamine / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/b008065i