Technology Process of (2S)-2-(2-chlorophenyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]-1,4-diazepane
There total 7 articles about (2S)-2-(2-chlorophenyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]-1,4-diazepane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
for 18h;
DOI:10.1039/c3ob42512f
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: thionyl chloride; triethylamine; 1H-imidazole / dichloromethane / -60 - 20 °C
2.1: ruthenium(III) chloride trihydrate; sodium periodate / acetonitrile; water / 2 h / 0 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h
3.2: 20 h
4.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 h
With
1H-imidazole; sodium periodate; thionyl chloride; ruthenium(III) chloride trihydrate; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob42512f
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium carbonate / water; 1,4-dioxane / 15 h / 0 - 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 96 h / 0 - 70 °C
3.1: thionyl chloride; triethylamine; 1H-imidazole / dichloromethane / -60 - 20 °C
4.1: ruthenium(III) chloride trihydrate; sodium periodate / acetonitrile; water / 2 h / 0 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h
5.2: 20 h
6.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 h
With
1H-imidazole; sodium periodate; lithium aluminium tetrahydride; thionyl chloride; ruthenium(III) chloride trihydrate; sodium hydride; sodium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob42512f
