4-[1-fluoro-2-(methoxyamino)-1-methyl-2-oxoethyl]phenyl trifluoromethanesulfonate

Base Information

Chemical Name:4-[1-fluoro-2-(methoxyamino)-1-methyl-2-oxoethyl]phenyl trifluoromethanesulfonate
CAS No.:1034809-21-6
Molecular Formula:C₁₁H₁₁F₄NO₅S
Molecular Weight:345.272
Hs Code.:

Synonyms:4-[1-fluoro-2-(methoxyamino)-1-methyl-2-oxoethyl]phenyl trifluoromethanesulfonate

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Chemical Property of 4-[1-fluoro-2-(methoxyamino)-1-methyl-2-oxoethyl]phenyl trifluoromethanesulfonate

Chemical Property:

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Technology Process of 4-[1-fluoro-2-(methoxyamino)-1-methyl-2-oxoethyl]phenyl trifluoromethanesulfonate

There total 7 articles about 4-[1-fluoro-2-(methoxyamino)-1-methyl-2-oxoethyl]phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-fluoro-2-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)propanoic acid chloride

: 593-56-6
N-methoxylamine hydrochloride

: 1034809-21-6
4-[1-fluoro-2-(methoxyamino)-1-methyl-2-oxoethyl]phenyl trifluoromethanesulfonate

Guidance literature:: In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1034809-42-1
4-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)phenyl trifluoromethanesulfonate

: 1034809-21-6
4-[1-fluoro-2-(methoxyamino)-1-methyl-2-oxoethyl]phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 1.5 h / -78 °C

1.2: 20 °C

2.1: ammonia / methanol / 20 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / -60 - 20 °C

4.1: hydrogenchloride; water / 1,4-dioxane / 48 h / Heating / reflux

5.1: thionyl chloride / 3 h / Heating / reflux

6.1: dichloromethane / 0 - 20 °C

With hydrogenchloride; thionyl chloride; diethylamino-sulfur trifluoride; ammonia; water; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane;

Reference yield:

: 1034809-15-8
4-(1-amino-2-fluoro-1-oxopropan-2-yl)phenyl trifluoromethanesulfonate

: 1034809-21-6
4-[1-fluoro-2-(methoxyamino)-1-methyl-2-oxoethyl]phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / 1,4-dioxane / 48 h / Heating / reflux

2: thionyl chloride / 3 h / Heating / reflux

3: dichloromethane / 0 - 20 °C

With hydrogenchloride; thionyl chloride; water; In 1,4-dioxane; dichloromethane;