Cladinose

Base Information

• Chemical Name: Cladinose
• CAS No.: 470-12-2
• Molecular Formula: C₈H₁₆O₄
• Molecular Weight: 176.213
• DSSTox Substance ID: DTXSID60197001
• Nikkaji Number: J2.369.552I
• Wikipedia: Cladinose
• Mol file: 470-12-2.mol

Synonyms:cladinose

Chemical Property of Cladinose

Chemical Property:

• Vapor Pressure: 2.06E-05mmHg at 25°C
• Boiling Point: 323.5°Cat760mmHg
• Flash Point: 127.7°C
• PSA: 66.76000
• Density: 1.1g/cm³
• LogP: -0.27780
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: Acetone (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 176.10485899
• Heavy Atom Count: 12
• Complexity: 148

Purity/Quality:

97% ^*data from raw suppliers

Cladinose ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C(C)(CC=O)OC)O)O
• Isomeric SMILES: C[C@H]([C@H]([C@](C)(CC=O)OC)O)O
• Uses: A hexose sugar commonly associated with the macrolide ring of relevant antibiotics.

Technology Process of Cladinose

There total 6 articles about Cladinose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

Zithromax(R) (83905-01-5,92470-27-4) → cladinose (3758-45-0,470-12-2) + (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)‐11-((2S,3R,4S,6R)‐4-dimethylamino-3-hydroxy-6-methyl-tetrahydropyran-2-yloxy)-2-ethyl-3,4,10,13-tetrahydroxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopetadecan-15-one (117693-41-1)

Guidance literature:

With hydrogenchloride; In water; acetone;

DOI:10.1039/c4md00220b

Reference yield: 40.0%

clarithromycin (81103-11-9) → cladinose (3758-45-0,470-12-2) + 3-O-descladinosylclarithromycin (118058-74-5)

Guidance literature:

With hydrogenchloride; In water; acetone;

DOI:10.1039/c4md00220b

Reference yield:

erythromycin (114-07-8) → cladinose (3758-45-0,470-12-2)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01641a005

upstream raw materials:

erythromycin

clarithromycin

Zithromax(R)

Refernces