cis-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-acetonitrile

Base Information

Chemical Name:cis-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-acetonitrile
CAS No.:1202008-50-1
Molecular Formula:C₂₀H₃₀FNOSi
Molecular Weight:347.548
Hs Code.:

Synonyms:cis-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-acetonitrile

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Chemical Property of cis-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-acetonitrile

Chemical Property:

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Technology Process of cis-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-acetonitrile

There total 8 articles about cis-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: potassium cyanide

: 1202008-51-2
C₂₀H₃₃FO₄SSi

: 1202008-50-1
cis-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-acetonitrile

Guidance literature:: With 18-crown-6 ether; In N,N-dimethyl-formamide; at 20 - 155 ℃; for 52h;

Reference yield:

: 459-22-3
4-fluorophenylacetonitrile

: 1202008-50-1
cis-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-acetonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium methylate / tetrahydrofuran; methanol / 20 - 50 °C

2.1: hydrogenchloride / ethanol; water / 40 h / Reflux

3.1: sodium tetrahydroborate / ethanol / -20 - 20 °C

4.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C

5.1: diisobutylaluminium hydride / dichloromethane / 1.33 h / -70 °C

5.2: 2 h / 20 °C

6.1: sodium tetrahydroborate / methanol / 17 h / 0 - 20 °C

7.1: triethylamine / dichloromethane / 0 °C

7.2: 2.5 h / 0 °C

8.1: 18-crown-6 ether / N,N-dimethyl-formamide / 52 h / 20 - 155 °C

With 2,6-dimethylpyridine; hydrogenchloride; sodium tetrahydroborate; 18-crown-6 ether; sodium methylate; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1202007-21-3
C₁₉H₃₁FO₂Si

: 1202008-50-1
cis-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 °C

1.2: 2.5 h / 0 °C

2.1: 18-crown-6 ether / N,N-dimethyl-formamide / 52 h / 20 - 155 °C

With 18-crown-6 ether; triethylamine; In dichloromethane; N,N-dimethyl-formamide;