4-[(1E)-3-({8-[(tert-butoxycarbonyl)amino]octyl}amino)-3-oxoprop-1-enyl]phenyl acetate

Base Information

• Chemical Name: 4-[(1E)-3-({8-[(tert-butoxycarbonyl)amino]octyl}amino)-3-oxoprop-1-enyl]phenyl acetate
• CAS No.: 556065-57-7
• Molecular Formula: C₂₄H₃₆N₂O₅
• Molecular Weight: 432.56
• Mol file: 556065-57-7.mol

Synonyms:4-[(1E)-3-({8-[(tert-butoxycarbonyl)amino]octyl}amino)-3-oxoprop-1-enyl]phenyl acetate

Chemical Property of 4-[(1E)-3-({8-[(tert-butoxycarbonyl)amino]octyl}amino)-3-oxoprop-1-enyl]phenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(1E)-3-({8-[(tert-butoxycarbonyl)amino]octyl}amino)-3-oxoprop-1-enyl]phenyl acetate

There total 5 articles about 4-[(1E)-3-({8-[(tert-butoxycarbonyl)amino]octyl}amino)-3-oxoprop-1-enyl]phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

p-acetoxycinnamoyl chloride (53901-95-4,108608-06-6,58523-18-5) + tert-butyl N-(8-aminooctyl)carbamate (88829-82-7) → 4-[(1E)-3-({8-[(tert-butoxycarbonyl)amino]octyl}amino)-3-oxoprop-1-enyl]phenyl acetate (556065-57-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/S0031-9422(03)00133-X

Reference yield:

1,8-diaminooctan (373-44-4) → 4-[(1E)-3-({8-[(tert-butoxycarbonyl)amino]octyl}amino)-3-oxoprop-1-enyl]phenyl acetate (556065-57-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / methanol / -78 - 20 °C

2: 99 percent / tetrahydrofuran / 20 °C

3: 99 percent / aq. NH₄OH / methanol / 48 h / Heating

4: 60 percent / Et₃N / CH₂Cl₂ / 20 °C

With ammonium hydroxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0031-9422(03)00133-X

Reference yield:

4-acetoxycinnamic acid (27542-85-4) → 4-[(1E)-3-({8-[(tert-butoxycarbonyl)amino]octyl}amino)-3-oxoprop-1-enyl]phenyl acetate (556065-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2; DMF / CH₂Cl₂ / 1 h / Heating

2: 60 percent / Et₃N / CH₂Cl₂ / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/S0031-9422(03)00133-X

upstream raw materials:

p-acetoxycinnamoyl chloride

tert-butyl N-(8-aminooctyl)carbamate

1,8-diaminooctan

4-acetoxycinnamic acid