4-[1-(2-Mercaptomethyl-phenyl)-meth-(E)-ylidene]-10-methoxy-1-phenyl-deca-1,5-diyn-3-ol

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Chemical Name:4-[1-(2-Mercaptomethyl-phenyl)-meth-(E)-ylidene]-10-methoxy-1-phenyl-deca-1,5-diyn-3-ol
CAS No.:216573-04-5
Molecular Formula:C₂₅H₂₆O₂S
Molecular Weight:390.546
Hs Code.:

Synonyms:4-[1-(2-Mercaptomethyl-phenyl)-meth-(E)-ylidene]-10-methoxy-1-phenyl-deca-1,5-diyn-3-ol

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Chemical Property of 4-[1-(2-Mercaptomethyl-phenyl)-meth-(E)-ylidene]-10-methoxy-1-phenyl-deca-1,5-diyn-3-ol

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Technology Process of 4-[1-(2-Mercaptomethyl-phenyl)-meth-(E)-ylidene]-10-methoxy-1-phenyl-deca-1,5-diyn-3-ol

There total 11 articles about 4-[1-(2-Mercaptomethyl-phenyl)-meth-(E)-ylidene]-10-methoxy-1-phenyl-deca-1,5-diyn-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52753-91-0,132316-45-1
(E)-methyl 3-(2-formylphenyl)acrylate

: 216573-04-5
4-[1-(2-Mercaptomethyl-phenyl)-meth-(E)-ylidene]-10-methoxy-1-phenyl-deca-1,5-diyn-3-ol

Guidance literature:: Multi-step reaction with 12 steps

1: 55 percent / NaBH₄ / methanol; H₂O / 2 h / 0 °C

2: 98 percent / dimethylformamide / 0.25 h / Ambient temperature

3: DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

4: PDC, mol. sieves 4A / CH₂Cl₂ / 1 h / Ambient temperature

5: Br₂ / CH₂Cl₂ / 0 °C

6: Et₃N / 2 h / Ambient temperature

7: 74 percent / Pd⁽⁰⁾-CuI(I), Et₃N / tetrahydrofuran / 1 h / Ambient temperature

8: tetrahydrofuran / -78 °C

9: DMAP / CH₂Cl₂ / Ambient temperature

10: PPTS / methanol / 14 h / Ambient temperature

11: Ph₃P, DEAD / tetrahydrofuran / 1 h / 0 - 20 °C

12: K₂CO₃, H₂O / methanol / 0.25 h / Ambient temperature

With dmap; sodium tetrahydroborate; copper(l) iodide; dipyridinium dichromate; 4 A molecular sieve; water; bromine; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; palladium; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01834-6

Reference yield:

: 216572-78-0
3-(2-hydroxymethylphenyl)acrylic acid methyl ester

: 216573-04-5
4-[1-(2-Mercaptomethyl-phenyl)-meth-(E)-ylidene]-10-methoxy-1-phenyl-deca-1,5-diyn-3-ol

Guidance literature:: Multi-step reaction with 11 steps

1: 98 percent / dimethylformamide / 0.25 h / Ambient temperature

2: DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

3: PDC, mol. sieves 4A / CH₂Cl₂ / 1 h / Ambient temperature

4: Br₂ / CH₂Cl₂ / 0 °C

5: Et₃N / 2 h / Ambient temperature

6: 74 percent / Pd⁽⁰⁾-CuI(I), Et₃N / tetrahydrofuran / 1 h / Ambient temperature

7: tetrahydrofuran / -78 °C

8: DMAP / CH₂Cl₂ / Ambient temperature

9: PPTS / methanol / 14 h / Ambient temperature

10: Ph₃P, DEAD / tetrahydrofuran / 1 h / 0 - 20 °C

11: K₂CO₃, H₂O / methanol / 0.25 h / Ambient temperature

With dmap; copper(l) iodide; dipyridinium dichromate; 4 A molecular sieve; water; bromine; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; palladium; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01834-6

Reference yield:

: 216572-80-4
(E)-3-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-propenal

: 216573-04-5
4-[1-(2-Mercaptomethyl-phenyl)-meth-(E)-ylidene]-10-methoxy-1-phenyl-deca-1,5-diyn-3-ol

Guidance literature:: Multi-step reaction with 8 steps

1: Br₂ / CH₂Cl₂ / 0 °C

2: Et₃N / 2 h / Ambient temperature

3: 74 percent / Pd⁽⁰⁾-CuI(I), Et₃N / tetrahydrofuran / 1 h / Ambient temperature

4: tetrahydrofuran / -78 °C

5: DMAP / CH₂Cl₂ / Ambient temperature

6: PPTS / methanol / 14 h / Ambient temperature

7: Ph₃P, DEAD / tetrahydrofuran / 1 h / 0 - 20 °C

8: K₂CO₃, H₂O / methanol / 0.25 h / Ambient temperature

With dmap; copper(l) iodide; water; bromine; pyridinium p-toluenesulfonate; potassium carbonate; palladium; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(98)01834-6