N-<4-phenyl>-2-(tert-butyloxycarbonylamino)propanamide

Base Information

• Chemical Name: N-<4-phenyl>-2-(tert-butyloxycarbonylamino)propanamide
• CAS No.: 220903-71-9
• Molecular Formula: C₁₈H₂₇Cl₂N₃O₃
• Molecular Weight: 404.337
• Mol file: 220903-71-9.mol

Synonyms:N-<4-phenyl>-2-(tert-butyloxycarbonylamino)propanamide

Chemical Property of N-<4-phenyl>-2-(tert-butyloxycarbonylamino)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of N-<4-phenyl>-2-(tert-butyloxycarbonylamino)propanamide

There total 1 articles about N-<4-phenyl>-2-(tert-butyloxycarbonylamino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-t-butyloxycarbonyl-DL-alanine (3744-87-4,7764-95-6,15761-38-3) + N,N-bis(2-chloroethyl)benzene-1,4-diamine hydrochloride (945-68-6) → N-<4-phenyl>-2-(tert-butyloxycarbonylamino)propanamide (220903-71-9)

Guidance literature:

With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine; Yield given; Multistep reaction; 1.) DMF, 0 deg C, 2.) DMF, 20 deg C, 1.5 h;

DOI:10.1021/jm960783s

Reference yield: 93.0%

N-<4-phenyl>-2-(tert-butyloxycarbonylamino)propanamide (220903-71-9) → 2-amino-N-<4-phenyl>propanamide (220903-72-0)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 2h;

DOI:10.1021/jm960783s

Reference yield:

N-<4-phenyl>-2-(tert-butyloxycarbonylamino)propanamide (220903-71-9) → N-<4-phenyl>-2-<(4-carboxy-2,6-dinitrophenyl)amino>propanamide (220903-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / TFA / 2 h / 20 °C

2: 71 percent / diisopropylamine / tetrahydrofuran / 12 h / 20 °C

With diisopropylamine; trifluoroacetic acid; In tetrahydrofuran;

DOI:10.1021/jm960783s

upstream raw materials:

N-t-butyloxycarbonyl-DL-alanine

N,N-bis(2-chloroethyl)benzene-1,4-diamine hydrochloride

Downstream raw materials:

2-amino-N-<4-phenyl>propanamide

N-<4-phenyl>-2-<(4-carboxy-2,6-dinitrophenyl)amino>propanamide