(1S,3R)-3-(2-Acetoxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid

Base Information

• Chemical Name: (1S,3R)-3-(2-Acetoxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid
• CAS No.: 81980-00-9
• Molecular Formula: C₁₆H₂₀O₄
• Molecular Weight: 276.332
• Mol file: 81980-00-9.mol

Synonyms:(1S,3R)-3-(2-Acetoxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid

Chemical Property of (1S,3R)-3-(2-Acetoxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,3R)-3-(2-Acetoxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid

There total 1 articles about (1S,3R)-3-(2-Acetoxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2,2-dimethyl-3-(2-acetoxy-2-phenylethyl)-cis-1-(2-phenylprop-1-enyl) cyclopropane (81979-98-8,82009-60-7) → (1S,3R)-3-(2-Acetoxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid (81980-00-9)

Guidance literature:

With potassium permanganate; In water; acetic acid; acetone; at 40 - 50 ℃; for 2h;

Reference yield:

(1S,3R)-3-(2-Acetoxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid (81980-00-9) → 1S-cis-2,2-dimethyl-3-(2-phenyl-2-hydroxyethyl) cyclopropane carboxylic acid δ-lactone (81980-02-1)

Guidance literature:

Multi-step reaction with 4 steps

2: silicic acid / petroleum ether / 3 h

3: NaOH / methanol; H₂O / 3 h / Heating

4: PTS / benzene / 4 h / Heating

With sodium hydroxide; pyridinium p-toluenesulfonate; silicic acid; In methanol; water; Petroleum ether; benzene;

Reference yield:

(1S,3R)-3-(2-Acetoxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid (81980-00-9) → (1S,3R)-3-(2-Hydroxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid

Guidance literature:

Multi-step reaction with 3 steps

2: silicic acid / petroleum ether / 3 h

3: NaOH / methanol; H₂O / 3 h / Heating

With sodium hydroxide; silicic acid; In methanol; water; Petroleum ether;

upstream raw materials:

2,2-dimethyl-3-(2-acetoxy-2-phenylethyl)-cis-1-(2-phenylprop-1-enyl) cyclopropane

Downstream raw materials:

(1S,3R)-3-(2-Acetoxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid methyl ester

1S-cis-2,2-dimethyl-3-(2-phenyl-2-hydroxyethyl) cyclopropane carboxylic acid δ-lactone

2-Benzoyl-4,4-dimethyl-cyclopent-2-ene-1-one

methyl 2,2-dimethyl-3-(2-oxo-2-phenylethyl) cyclopropane-cis-1-carboxylate