methyl 2,2-dimethyl-3-(2-oxo-2-phenylethyl) cyclopropane-cis-1-carboxylate

Base Information

• Chemical Name: methyl 2,2-dimethyl-3-(2-oxo-2-phenylethyl) cyclopropane-cis-1-carboxylate
• CAS No.: 81979-94-4
• Molecular Formula: C₁₅H₁₈O₃
• Molecular Weight: 246.306
• Mol file: 81979-94-4.mol

Synonyms:methyl 2,2-dimethyl-3-(2-oxo-2-phenylethyl) cyclopropane-cis-1-carboxylate

Chemical Property of methyl 2,2-dimethyl-3-(2-oxo-2-phenylethyl) cyclopropane-cis-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2,2-dimethyl-3-(2-oxo-2-phenylethyl) cyclopropane-cis-1-carboxylate

There total 3 articles about methyl 2,2-dimethyl-3-(2-oxo-2-phenylethyl) cyclopropane-cis-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 2,2,-dimethyl-3-(2-hydroxy-2-phenylethyl)cyclopropropane-cis-1-carboxylate (81980-01-0) → methyl 2,2-dimethyl-3-(2-oxo-2-phenylethyl) cyclopropane-cis-1-carboxylate (81979-94-4)

Guidance literature:

With chromic acid; In acetone; 1.) -10 deg C, 2.) 0-5 deg C, 1 hr;

Reference yield:

(1S,3R)-3-(2-Acetoxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid (81980-00-9) → methyl 2,2-dimethyl-3-(2-oxo-2-phenylethyl) cyclopropane-cis-1-carboxylate (81979-94-4)

Guidance literature:

Multi-step reaction with 3 steps

2: silicic acid / petroleum ether / 3 h

3: 85 percent / Jones' chromic acid reagents / acetone / 1.) -10 deg C, 2.) 0-5 deg C, 1 hr

With chromic acid; silicic acid; In acetone; Petroleum ether;

Reference yield:

(1S,3R)-3-(2-Acetoxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid methyl ester (81979-99-9) → methyl 2,2-dimethyl-3-(2-oxo-2-phenylethyl) cyclopropane-cis-1-carboxylate (81979-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: silicic acid / petroleum ether / 3 h

2: 85 percent / Jones' chromic acid reagents / acetone / 1.) -10 deg C, 2.) 0-5 deg C, 1 hr

With chromic acid; silicic acid; In acetone; Petroleum ether;

upstream raw materials:

methyl 2,2,-dimethyl-3-(2-hydroxy-2-phenylethyl)cyclopropropane-cis-1-carboxylate

(1S,3R)-3-(2-Acetoxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid

(1S,3R)-3-(2-Acetoxy-2-phenyl-ethyl)-2,2-dimethyl-cyclopropanecarboxylic acid methyl ester

Downstream raw materials:

Methyl 3,3-dimethyl-6-phenylhepta-4,6-dienoate

2-Benzoyl-4,4-dimethyl-cyclopent-2-ene-1-one

3-phenoxybenzyl cis(+/-) 2,2,-dimethyl-3-(2-phenyl-2-chlorovinyl)cyclopropanecarboxylate

methyl cis(+/-) 2,2-dimethyl-3-(2-phenyl-2-chlorovinyl)cyclopropanecarboxylate