(S)-1-phenylpentyl acetate

Base Information

• Chemical Name: (S)-1-phenylpentyl acetate
• CAS No.: 87190-42-9
• Molecular Formula: C₁₃H₁₈O₂
• Molecular Weight: 206.285
• Mol file: 87190-42-9.mol

Synonyms:(S)-1-phenylpentyl acetate

Chemical Property of (S)-1-phenylpentyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-phenylpentyl acetate

There total 28 articles about (S)-1-phenylpentyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

vinyl acetate (108-05-4,9003-20-7) + 1-Phenyl-1-pentanol (583-03-9) → (S)-(-)-1-phenylpentanol (33652-83-4) + (R)-1-phenylpentan-1-ol (19641-53-3) + (R)-(1-phenyl)-1-pentyl acetate (38488-01-6,87190-42-9,123880-11-5,87190-35-0)

Guidance literature:

1-Phenyl-1-pentanol; With Pseudomonas aeruginosa lipase; In isopropyl alcohol; at 30 ℃; for 0.5h; Enzymatic reaction;

vinyl acetate; In isopropyl alcohol; at 30 ℃; for 34h; optical yield given as %ee; enantioselective reaction; Enzymatic reaction;

DOI:10.1016/j.tet.2009.09.058

Reference yield: 15.0%

1-phenyl-1-(acetyloxy)pentane (38488-01-6) → (S)-(-)-1-phenylpentanol (33652-83-4) + (R)-1-phenylpentan-1-ol (19641-53-3) + (S)-1-phenylpentyl acetate (87190-42-9) + (R)-(1-phenyl)-1-pentyl acetate (38488-01-6,87190-42-9,123880-11-5,87190-35-0)

Guidance literature:

With Candida antarctica lipase B mutant WB₁₅ (W₁₀₄V+A₂₈₁L+A₂₈₂K); water; In aq. phosphate buffer; acetonitrile; at 37 ℃; for 36h; pH=7.5; Reagent/catalyst; enantioselective reaction; Resolution of racemate;

DOI:10.1002/adsc.201800711

Reference yield: 15.0%

1-phenyl-1-(acetyloxy)pentane (38488-01-6) → (S)-(-)-1-phenylpentanol (33652-83-4) + (R)-1-phenylpentan-1-ol (19641-53-3) + (S)-1-phenylpentyl acetate (87190-42-9) + (R)-(1-phenyl)-1-pentyl acetate (38488-01-6,87190-42-9,123880-11-5,87190-35-0)

Guidance literature:

With Candida antarctica lipase B mutant WB₁₅ (W₁₀₄V+A₂₈₁L+A₂₈₂K); water; In aq. phosphate buffer; acetonitrile; at 37 ℃; for 36h; pH=7.5; Reagent/catalyst; enantioselective reaction; Resolution of racemate;

DOI:10.1002/adsc.201800711

upstream raw materials:

(S)-(-)-1-phenylpentanol

acetic anhydride

1-Phenyl-1-pentanol

(-)-(S)-N,N-dimethyl-1-phenylethylamine

Downstream raw materials:

(R)-1-phenylpentan-1-ol

Refernces

• 1、 Cen, Yixin,Li, Danyang,Xu, Jian,Wu, Qiongsi,Wu, Qi,Lin, Xianfu. "Highly Focused Library-Based Engineering of Candida antarctica Lipase B with (S)-Selectivity Towards sec-Alcohols". supporting information. p. 126 - 134. Retrieved 2018/12/05.
• 2、 Ema, Tadashi,Nakano, Yasuko,Yoshida, Daiki,Kamata, Shusuke,Sakai, Takashi. "Redesign of enzyme for improving catalytic activity and enantioselectivity toward poor substrates: Manipulation of the transition state". supporting information; experimental part. p. 6299 - 6308. Retrieved 2012/09/05.