3-{[3,5-bis(trifluoromethyl)benzyl]}amino-4-{[(R,R)-2-aminocyclohexyl]amino}cyclobut-3-ene-1,2-dione

Base Information

• Chemical Name: 3-{[3,5-bis(trifluoromethyl)benzyl]}amino-4-{[(R,R)-2-aminocyclohexyl]amino}cyclobut-3-ene-1,2-dione
• CAS No.: 1449677-24-0
• Molecular Formula: C₁₉H₁₉F₆N₃O₂
• Molecular Weight: 435.369

Synonyms:3-{[3,5-bis(trifluoromethyl)benzyl]}amino-4-{[(R,R)-2-aminocyclohexyl]amino}cyclobut-3-ene-1,2-dione

Chemical Property of 3-{[3,5-bis(trifluoromethyl)benzyl]}amino-4-{[(R,R)-2-aminocyclohexyl]amino}cyclobut-3-ene-1,2-dione

Chemical Property:

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Technology Process of 3-{[3,5-bis(trifluoromethyl)benzyl]}amino-4-{[(R,R)-2-aminocyclohexyl]amino}cyclobut-3-ene-1,2-dione

There total 1 articles about 3-{[3,5-bis(trifluoromethyl)benzyl]}amino-4-{[(R,R)-2-aminocyclohexyl]amino}cyclobut-3-ene-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-methoxycyclobut-3-ene-1,2-dione (1073917-05-1) + (1R,2R)-1,2-diaminocyclohexane (20439-47-8) → 3-{[3,5-bis(trifluoromethyl)benzyl]}amino-4-{[(R,R)-2-aminocyclohexyl]amino}cyclobut-3-ene-1,2-dione (1449677-24-0)

Guidance literature:

In methanol; at 18 ℃; for 3h;

DOI:10.1002/adsc.201200658

Reference yield: 40.0%

1,5-dibromo-pentane (111-24-0) + 3-{[3,5-bis(trifluoromethyl)benzyl]}amino-4-{[(R,R)-2-aminocyclohexyl]amino}cyclobut-3-ene-1,2-dione (1449677-24-0) → 3-{[3,5-bis(trifluoromethyl)benzyl]amino}-4-{[(R,R)-2-( piperidine-1-yl)cyclohexyl]amino}cyclobut-3-ene-1,2-dione

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 90 ℃; for 26h;

DOI:10.1039/c3ob41709c

Reference yield: 24.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-{[3,5-bis(trifluoromethyl)benzyl]}amino-4-{[(R,R)-2-aminocyclohexyl]amino}cyclobut-3-ene-1,2-dione (1449677-24-0) → C21H23F6N3O2 (1449676-73-6)

Guidance literature:

With formic acid; In methanol; water; for 25h; Reflux;

DOI:10.1002/adsc.201200658

upstream raw materials:

3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-methoxycyclobut-3-ene-1,2-dione

(1R,2R)-1,2-diaminocyclohexane

Downstream raw materials:

C₂₁H₂₃F₆N₃O₂

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