5-{1-[4-(4-Methoxy-benzyloxy)-phenyl]-3-trimethylsilanyl-prop-2-ynyl}-2,2-dimethyl-[1,3]dioxane-4,6-dione

Base Information

• Chemical Name: 5-{1-[4-(4-Methoxy-benzyloxy)-phenyl]-3-trimethylsilanyl-prop-2-ynyl}-2,2-dimethyl-[1,3]dioxane-4,6-dione
• CAS No.: 115062-58-3
• Molecular Formula: C₂₆H₃₀O₆Si
• Molecular Weight: 466.606
• Mol file: 115062-58-3.mol

Synonyms:5-{1-[4-(4-Methoxy-benzyloxy)-phenyl]-3-trimethylsilanyl-prop-2-ynyl}-2,2-dimethyl-[1,3]dioxane-4,6-dione

Chemical Property of 5-{1-[4-(4-Methoxy-benzyloxy)-phenyl]-3-trimethylsilanyl-prop-2-ynyl}-2,2-dimethyl-[1,3]dioxane-4,6-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-{1-[4-(4-Methoxy-benzyloxy)-phenyl]-3-trimethylsilanyl-prop-2-ynyl}-2,2-dimethyl-[1,3]dioxane-4,6-dione

There total 1 articles about 5-{1-[4-(4-Methoxy-benzyloxy)-phenyl]-3-trimethylsilanyl-prop-2-ynyl}-2,2-dimethyl-[1,3]dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(trimethylsilyl)ethynylmagnesium bromide (61210-52-4) + 5-[[4-[(4-methoxyphenyl)methoxy]phenyl]methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (115062-69-6) → 5-{1-[4-(4-Methoxy-benzyloxy)-phenyl]-3-trimethylsilanyl-prop-2-ynyl}-2,2-dimethyl-[1,3]dioxane-4,6-dione (115062-58-3)

Guidance literature:

DOI:10.1021/jm00399a002

Reference yield:

5-{1-[4-(4-Methoxy-benzyloxy)-phenyl]-3-trimethylsilanyl-prop-2-ynyl}-2,2-dimethyl-[1,3]dioxane-4,6-dione (115062-58-3) → {2-[4-(4-Methoxy-benzyloxy)-phenyl]-but-3-enyl}-carbamic acid 4-methoxy-benzyl ester (115062-67-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) aq. pyridine, 2.) KF / 1.) 100 deg C, 2.) DMF, 50 deg C

2: 62 percent / diphenyl phosphorazidate, Et₃N / toluene / 100 °C

3: hydrogen / Pd/Ba₂CO₃ / CH₂Cl₂

With pyridine; potassium fluoride; diphenyl phosphoryl azide; hydrogen; triethylamine; palladium; In dichloromethane; toluene;

DOI:10.1021/jm00399a002

Reference yield:

5-{1-[4-(4-Methoxy-benzyloxy)-phenyl]-3-trimethylsilanyl-prop-2-ynyl}-2,2-dimethyl-[1,3]dioxane-4,6-dione (115062-58-3) → {2-[4-(4-Methoxy-benzyloxy)-phenyl]-but-3-ynyl}-carbamic acid 4-methoxy-benzyl ester (113036-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) aq. pyridine, 2.) KF / 1.) 100 deg C, 2.) DMF, 50 deg C

2: 62 percent / diphenyl phosphorazidate, Et₃N / toluene / 100 °C

With pyridine; potassium fluoride; diphenyl phosphoryl azide; triethylamine; In toluene;

DOI:10.1021/jm00399a002

upstream raw materials:

(trimethylsilyl)ethynylmagnesium bromide

5-[[4-[(4-methoxyphenyl)methoxy]phenyl]methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

Downstream raw materials:

3-(4-(4-methoxybenzyloxy)phenyl)pent-4-ynoic acid

{2-[4-(4-Methoxy-benzyloxy)-phenyl]-but-3-enyl}-carbamic acid 4-methoxy-benzyl ester

{2-[4-(4-Methoxy-benzyloxy)-phenyl]-but-3-ynyl}-carbamic acid 4-methoxy-benzyl ester