{2-[4-(4-Methoxy-benzyloxy)-phenyl]-but-3-ynyl}-carbamic acid 4-methoxy-benzyl ester

Base Information

• Chemical Name: {2-[4-(4-Methoxy-benzyloxy)-phenyl]-but-3-ynyl}-carbamic acid 4-methoxy-benzyl ester
• CAS No.: 113036-74-1
• Molecular Formula: C₂₇H₂₇NO₅
• Molecular Weight: 445.515
• Mol file: 113036-74-1.mol

Synonyms:{2-[4-(4-Methoxy-benzyloxy)-phenyl]-but-3-ynyl}-carbamic acid 4-methoxy-benzyl ester

Chemical Property of {2-[4-(4-Methoxy-benzyloxy)-phenyl]-but-3-ynyl}-carbamic acid 4-methoxy-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[4-(4-Methoxy-benzyloxy)-phenyl]-but-3-ynyl}-carbamic acid 4-methoxy-benzyl ester

There total 3 articles about {2-[4-(4-Methoxy-benzyloxy)-phenyl]-but-3-ynyl}-carbamic acid 4-methoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-Methoxybenzyl alcohol (105-13-5) + 3-(4-(4-methoxybenzyloxy)phenyl)pent-4-ynoic acid (113036-71-8) → {2-[4-(4-Methoxy-benzyloxy)-phenyl]-but-3-ynyl}-carbamic acid 4-methoxy-benzyl ester (113036-74-1)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In toluene; at 100 ℃;

DOI:10.1021/jm00399a002

Reference yield:

5-[[4-[(4-methoxyphenyl)methoxy]phenyl]methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (115062-69-6) → {2-[4-(4-Methoxy-benzyloxy)-phenyl]-but-3-ynyl}-carbamic acid 4-methoxy-benzyl ester (113036-74-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent

2: 1.) aq. pyridine, 2.) KF / 1.) 100 deg C, 2.) DMF, 50 deg C

3: 62 percent / diphenyl phosphorazidate, Et₃N / toluene / 100 °C

With pyridine; potassium fluoride; diphenyl phosphoryl azide; triethylamine; In toluene;

DOI:10.1021/jm00399a002

Reference yield:

5-{1-[4-(4-Methoxy-benzyloxy)-phenyl]-3-trimethylsilanyl-prop-2-ynyl}-2,2-dimethyl-[1,3]dioxane-4,6-dione (115062-58-3) → {2-[4-(4-Methoxy-benzyloxy)-phenyl]-but-3-ynyl}-carbamic acid 4-methoxy-benzyl ester (113036-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) aq. pyridine, 2.) KF / 1.) 100 deg C, 2.) DMF, 50 deg C

2: 62 percent / diphenyl phosphorazidate, Et₃N / toluene / 100 °C

With pyridine; potassium fluoride; diphenyl phosphoryl azide; triethylamine; In toluene;

DOI:10.1021/jm00399a002

upstream raw materials:

4-Methoxybenzyl alcohol

3-(4-(4-methoxybenzyloxy)phenyl)pent-4-ynoic acid

5-[[4-[(4-methoxyphenyl)methoxy]phenyl]methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

5-{1-[4-(4-Methoxy-benzyloxy)-phenyl]-3-trimethylsilanyl-prop-2-ynyl}-2,2-dimethyl-[1,3]dioxane-4,6-dione

Downstream raw materials:

{2-[4-(4-Methoxy-benzyloxy)-phenyl]-but-3-enyl}-carbamic acid 4-methoxy-benzyl ester

4-(1-Aminomethyl-prop-2-ynyl)-phenol