3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)-4-p-tolylfuran-2(5H)-one

Base Information

Chemical Name:3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)-4-p-tolylfuran-2(5H)-one
CAS No.:1330676-64-6
Molecular Formula:C₂₈H₂₃F₂N₃O₄
Molecular Weight:503.505
Hs Code.:

Synonyms:3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)-4-p-tolylfuran-2(5H)-one

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Chemical Property of 3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)-4-p-tolylfuran-2(5H)-one

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Technology Process of 3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)-4-p-tolylfuran-2(5H)-one

There total 5 articles about 3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)-4-p-tolylfuran-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1330676-53-3
2-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)acetic acid

: 4209-24-9
p-methylphenacyl chloride

: 1330676-64-6
3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)-4-p-tolylfuran-2(5H)-one

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃;
DOI:10.1016/j.bmcl.2011.06.022

Reference yield:

: 1330676-45-3
4-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzylidene)-2-phenyloxazol-5(4H)-one

: 1330676-64-6
3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)-4-p-tolylfuran-2(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 7 h / 80 - 90 °C

1.2: 0 - 20 °C

2.1: potassium carbonate / acetonitrile / 80 °C

With potassium carbonate; sodium hydroxide; In water; acetonitrile;
DOI:10.1016/j.bmcl.2011.06.022

Reference yield:

: 1330676-37-3
4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzaldehyde

: 1330676-64-6
3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)-4-p-tolylfuran-2(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate; acetic anhydride / 2 h / 85 °C / Inert atmosphere

2.1: sodium hydroxide / water / 7 h / 80 - 90 °C

2.2: 0 - 20 °C

3.1: potassium carbonate / acetonitrile / 80 °C

With sodium acetate; acetic anhydride; potassium carbonate; sodium hydroxide; In water; acetonitrile;
DOI:10.1016/j.bmcl.2011.06.022