Technology Process of dimethyl (R)-3-(benzyloxy)-2,2,6-trimethyl-2,3-dihydro-1H-indene-4, 5-dicarboxylate
There total 6 articles about dimethyl (R)-3-(benzyloxy)-2,2,6-trimethyl-2,3-dihydro-1H-indene-4, 5-dicarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-(((5,5-dimethyloct-2-en-7-yn-4-yl)oxy)methyl)benzene; dimethyl acetylenedicarboxylate;
In
toluene;
at 120 ℃;
Inert atmosphere;
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
toluene;
at 20 ℃;
Inert atmosphere;
DOI:10.1039/c4ob00300d
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere
2.2: 0.5 h / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
4.1: hydrogenchloride / water; acetone / 0.67 h / Inert atmosphere; Reflux
5.1: potassium carbonate / methanol / 16 h / 20 °C / Inert atmosphere
6.1: toluene / 120 °C / Inert atmosphere
6.2: 20 °C / Inert atmosphere
With
hydrogenchloride; n-butyllithium; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; acetone; toluene;
1.1: |Wittig Olefination / 1.2: |Wittig Olefination / 2.1: |Swern Oxidation / 2.2: |Swern Oxidation / 3.1: |Wittig Olefination / 3.2: |Wittig Olefination / 6.1: |Diels-Alder Cycloaddition;
DOI:10.1039/c4ob00300d
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: hydrogenchloride / water; acetone / 0.67 h / Inert atmosphere; Reflux
3.1: potassium carbonate / methanol / 16 h / 20 °C / Inert atmosphere
4.1: toluene / 120 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere
With
hydrogenchloride; n-butyllithium; potassium carbonate;
In
tetrahydrofuran; methanol; hexane; water; acetone; toluene;
1.1: |Wittig Olefination / 1.2: |Wittig Olefination / 4.1: |Diels-Alder Cycloaddition;
DOI:10.1039/c4ob00300d
