(2S,3S,6S)-6-(1-ethoxyethoxy)-2-[(3R)-3-phenyloxiranyl]-3,6-dihydro-2H-pyran-3-ol

Base Information

Chemical Name:(2S,3S,6S)-6-(1-ethoxyethoxy)-2-[(3R)-3-phenyloxiranyl]-3,6-dihydro-2H-pyran-3-ol
CAS No.:474126-22-2
Molecular Formula:C₁₇H₂₂O₅
Molecular Weight:306.359
Hs Code.:

Synonyms:(2S,3S,6S)-6-(1-ethoxyethoxy)-2-[(3R)-3-phenyloxiranyl]-3,6-dihydro-2H-pyran-3-ol

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Chemical Property of (2S,3S,6S)-6-(1-ethoxyethoxy)-2-[(3R)-3-phenyloxiranyl]-3,6-dihydro-2H-pyran-3-ol

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Technology Process of (2S,3S,6S)-6-(1-ethoxyethoxy)-2-[(3R)-3-phenyloxiranyl]-3,6-dihydro-2H-pyran-3-ol

There total 7 articles about (2S,3S,6S)-6-(1-ethoxyethoxy)-2-[(3R)-3-phenyloxiranyl]-3,6-dihydro-2H-pyran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 474126-21-1
(2S,3S,6S)-3-tert-butyldimethylsilanyloxy-6-(1-ethoxyethoxy)-2-[(3R)-3-phenyloxiranyl]-3,6-dihydro-2H-pyran

: 474126-22-2
(2S,3S,6S)-6-(1-ethoxyethoxy)-2-[(3R)-3-phenyloxiranyl]-3,6-dihydro-2H-pyran-3-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 2h;
DOI:10.1016/S0040-4020(02)00791-3

Reference yield:

: 129694-45-7
(2S)-6-Hydroxy-2-<(E)-styryl>-6H-pyran-3(2H)-one

: 474126-22-2
(2S,3S,6S)-6-(1-ethoxyethoxy)-2-[(3R)-3-phenyloxiranyl]-3,6-dihydro-2H-pyran-3-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / pyridinium toluene-p-sulphonate / CH₂Cl₂ / 3 h / 25 °C

2: 78 percent / NaBH₄; CeCl₃*7H₂O / methanol / -40 - 20 °C

3: 2.8 g / Ph₃P; DEAD / tetrahydrofuran / 0 - 20 °C

4: 82 percent / K₂CO₃ / methanol / 10 h / 20 °C

5: 95 percent / Et₃N; DMAP / CH₂Cl₂ / 8 h / 0 °C

6: 82 percent / NaHCO₃; p-CPBA / CH₂Cl₂ / 10 h / 25 °C

7: 80 percent / TBAF / tetrahydrofuran / 2 h / 25 °C

With dmap; sodium tetrahydroborate; cerium(III) chloride; p-chloroperbenzoic acid; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1016/S0040-4020(02)00791-3

Reference yield:

: 129694-46-8
(2S,6S)-6-(1-Ethoxyethoxy)-2-<(E)-styryl>-6H-pyran-3(2H)-one

: 474126-22-2
(2S,3S,6S)-6-(1-ethoxyethoxy)-2-[(3R)-3-phenyloxiranyl]-3,6-dihydro-2H-pyran-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / NaBH₄; CeCl₃*7H₂O / methanol / -40 - 20 °C

2: 2.8 g / Ph₃P; DEAD / tetrahydrofuran / 0 - 20 °C

3: 82 percent / K₂CO₃ / methanol / 10 h / 20 °C

4: 95 percent / Et₃N; DMAP / CH₂Cl₂ / 8 h / 0 °C

5: 82 percent / NaHCO₃; p-CPBA / CH₂Cl₂ / 10 h / 25 °C

6: 80 percent / TBAF / tetrahydrofuran / 2 h / 25 °C

With dmap; sodium tetrahydroborate; cerium(III) chloride; p-chloroperbenzoic acid; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1016/S0040-4020(02)00791-3