(R)-((1S,2S,4aS,10aR)-7-bromo-1-(hydroxymethyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

Base Information

Chemical Name:(R)-((1S,2S,4aS,10aR)-7-bromo-1-(hydroxymethyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate
CAS No.:1028386-47-1
Molecular Formula:C₂₆H₃₁BrO₃
Molecular Weight:471.434
Hs Code.:

Synonyms:(R)-((1S,2S,4aS,10aR)-7-bromo-1-(hydroxymethyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

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Chemical Property of (R)-((1S,2S,4aS,10aR)-7-bromo-1-(hydroxymethyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

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Technology Process of (R)-((1S,2S,4aS,10aR)-7-bromo-1-(hydroxymethyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

There total 1 articles about (R)-((1S,2S,4aS,10aR)-7-bromo-1-(hydroxymethyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1028386-63-1
(R)-((1S,2S,4aS,10aR)-7-bromo-1,4a-dimethyl-1-((triisopropylsilyloxy)methyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

: 1028386-47-1
(R)-((1S,2S,4aS,10aR)-7-bromo-1-(hydroxymethyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

Guidance literature:: (R)-((1S,2S,4aS,10aR)-7-bromo-1,4a-dimethyl-1-((triisopropylsilyloxy)methyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 12h;

With water; In tetrahydrofuran; at 20 ℃; optical yield given as %ee;
DOI:10.1021/ol800499p

Reference yield: 95.0%

: 1028386-47-1
(R)-((1S,2S,4aS,10aR)-7-bromo-1-(hydroxymethyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

: 1028386-64-2
(R)-((1S,2S,4aS,10aR)-7-bromo-1-formyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

Guidance literature:: (R)-((1S,2S,4aS,10aR)-7-bromo-1-(hydroxymethyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.0833333h;

With triethylamine; In dichloromethane; at -78 - 20 ℃; optical yield given as %ee;
DOI:10.1021/ol800499p