(R)-((1S,2S,4aS,10aR)-7-bromo-1,4a-dimethyl-1-((triisopropylsilyloxy)methyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

Base Information

Chemical Name:(R)-((1S,2S,4aS,10aR)-7-bromo-1,4a-dimethyl-1-((triisopropylsilyloxy)methyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate
CAS No.:1028386-63-1
Molecular Formula:C₃₅H₅₁BrO₃Si
Molecular Weight:627.778
Hs Code.:

Synonyms:(R)-((1S,2S,4aS,10aR)-7-bromo-1,4a-dimethyl-1-((triisopropylsilyloxy)methyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-((1S,2S,4aS,10aR)-7-bromo-1,4a-dimethyl-1-((triisopropylsilyloxy)methyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

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Technology Process of (R)-((1S,2S,4aS,10aR)-7-bromo-1,4a-dimethyl-1-((triisopropylsilyloxy)methyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

There total 1 articles about (R)-((1S,2S,4aS,10aR)-7-bromo-1,4a-dimethyl-1-((triisopropylsilyloxy)methyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1028386-32-4
(R)-((1S,2S,4aS,10aR)-7-bromo-1,4a-dimethyl-1-((triisopropylsilyloxy)methyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methanol

: 108-24-7
acetic anhydride

: 1028386-63-1
(R)-((1S,2S,4aS,10aR)-7-bromo-1,4a-dimethyl-1-((triisopropylsilyloxy)methyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 - 20 ℃; optical yield given as %ee;
DOI:10.1021/ol800499p

Reference yield: 94.0%

: 1028386-63-1
(R)-((1S,2S,4aS,10aR)-7-bromo-1,4a-dimethyl-1-((triisopropylsilyloxy)methyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

: 1028386-47-1
(R)-((1S,2S,4aS,10aR)-7-bromo-1-(hydroxymethyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate

Guidance literature:: (R)-((1S,2S,4aS,10aR)-7-bromo-1,4a-dimethyl-1-((triisopropylsilyloxy)methyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl)(phenyl)methyl acetate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 12h;

With water; In tetrahydrofuran; at 20 ℃; optical yield given as %ee;
DOI:10.1021/ol800499p