4-<<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>methyl>pyridine

Base Information

Chemical Name:4-<<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>methyl>pyridine
CAS No.:142843-27-4
Molecular Formula:C₃₈H₅₃N₇O₆S
Molecular Weight:735.948
Hs Code.:

Synonyms:4-<<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>methyl>pyridine

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Chemical Property of 4-<<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>methyl>pyridine

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Technology Process of 4-<<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>methyl>pyridine

There total 6 articles about 4-<<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>methyl>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 3731-53-1
4-(aminomethyl)pyridine

: 142843-23-0
2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetic acid

: 142843-27-4
4-<<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>methyl>pyridine

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; for 15h; Ambient temperature;
DOI:10.1021/jm00093a009

Reference yield:

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 142843-27-4
4-<<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>methyl>pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / triethylamine / ethanol

2: ethanolic HCl / 1 h / Ambient temperature

3: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), triethylamine / CH₂Cl₂ / 17 h / Ambient temperature

4: 53 percent / K₂CO₃ / ethanol / 3 h / Ambient temperature

5: 42 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), triethylamine / CH₂Cl₂ / 15 h / Ambient temperature

With hydrogenchloride; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00093a009

Reference yield:

: ((2R,3S)-3-Amino-4-cyclohexyl-2-hydroxy-butylsulfanyl)-acetic acid ethyl ester

: 142843-27-4
4-<<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>methyl>pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), triethylamine / CH₂Cl₂ / 17 h / Ambient temperature

2: 53 percent / K₂CO₃ / ethanol / 3 h / Ambient temperature

3: 42 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), triethylamine / CH₂Cl₂ / 15 h / Ambient temperature

With potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00093a009