((2R,3R,4S)-4-Benzyloxy-2-{3-[(2R,4R,4aS,6R,7R,8aR)-7-benzyloxy-6-benzyloxymethyl-4-(4-methoxy-benzyloxy)-octahydro-pyrano[3,2-b]pyran-2-yl]-prop-2-ynyl}-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane

Base Information

Chemical Name:((2R,3R,4S)-4-Benzyloxy-2-{3-[(2R,4R,4aS,6R,7R,8aR)-7-benzyloxy-6-benzyloxymethyl-4-(4-methoxy-benzyloxy)-octahydro-pyrano[3,2-b]pyran-2-yl]-prop-2-ynyl}-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane
CAS No.:370886-87-6
Molecular Formula:C₅₂H₆₆O₉Si
Molecular Weight:863.176
Hs Code.:

((2R,3R,4S)-4-Benzyloxy-2-{3-[(2R,4R,4aS,6R,7R,8aR)-7-benzyloxy-6-benzyloxymethyl-4-(4-methoxy-benzyloxy)-octahydro-pyrano[3,2-b]pyran-2-yl]-prop-2-ynyl}-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane

Synonyms:((2R,3R,4S)-4-Benzyloxy-2-{3-[(2R,4R,4aS,6R,7R,8aR)-7-benzyloxy-6-benzyloxymethyl-4-(4-methoxy-benzyloxy)-octahydro-pyrano[3,2-b]pyran-2-yl]-prop-2-ynyl}-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane

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Chemical Property of ((2R,3R,4S)-4-Benzyloxy-2-{3-[(2R,4R,4aS,6R,7R,8aR)-7-benzyloxy-6-benzyloxymethyl-4-(4-methoxy-benzyloxy)-octahydro-pyrano[3,2-b]pyran-2-yl]-prop-2-ynyl}-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane

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Technology Process of ((2R,3R,4S)-4-Benzyloxy-2-{3-[(2R,4R,4aS,6R,7R,8aR)-7-benzyloxy-6-benzyloxymethyl-4-(4-methoxy-benzyloxy)-octahydro-pyrano[3,2-b]pyran-2-yl]-prop-2-ynyl}-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane

There total 29 articles about ((2R,3R,4S)-4-Benzyloxy-2-{3-[(2R,4R,4aS,6R,7R,8aR)-7-benzyloxy-6-benzyloxymethyl-4-(4-methoxy-benzyloxy)-octahydro-pyrano[3,2-b]pyran-2-yl]-prop-2-ynyl}-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1053655-14-3
(2R,4R,4aS,6R,7R,8aR)-7-Benzyloxy-2-{3-[(2R,3R,4S)-4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-prop-1-ynyl}-6-benzyloxymethyl-4-(4-methoxy-benzyloxy)-octahydro-pyrano[3,2-b]pyran-2-ol

: 370886-87-6
((2R,3R,4S)-4-Benzyloxy-2-{3-[(2R,4R,4aS,6R,7R,8aR)-7-benzyloxy-6-benzyloxymethyl-4-(4-methoxy-benzyloxy)-octahydro-pyrano[3,2-b]pyran-2-yl]-prop-2-ynyl}-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at -30 ℃;
DOI:10.1016/S0040-4039(01)01067-X

Reference yield:

: 2873-29-2
D-glucal triacetate

: 370886-87-6
((2R,3R,4S)-4-Benzyloxy-2-{3-[(2R,4R,4aS,6R,7R,8aR)-7-benzyloxy-6-benzyloxymethyl-4-(4-methoxy-benzyloxy)-octahydro-pyrano[3,2-b]pyran-2-yl]-prop-2-ynyl}-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 13 steps

1: 100 percent / H₂ / Pd/C / methanol / 20 °C

2: 100 percent / NaoMe / methanol / 20 °C

3: 100 percent / PPTS / dimethylformamide / 20 °C

4: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

5: L-selectride / tetrahydrofuran / -78 °C

6: NaH / dimethylformamide / 0 - 20 °C

7: p-TsOH / methanol / 20 °C

8: 2,6-lutidine / CH₂Cl₂ / -78 °C

9: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

10: 100 percent / K₂CO₃ / methanol / 20 °C

11: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

12: Et₃SiH; BF₃*OEt₂ / CH₂Cl₂ / -30 °C

With 2,6-dimethylpyridine; triethylsilane; n-butyllithium; oxalyl dichloride; boron trifluoride diethyl etherate; hydrogen; sodium methylate; pyridinium p-toluenesulfonate; L-Selectride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)01067-X

Reference yield:

: 370887-48-2
(2R,3S,4S)-4-Benzyloxy-2-hydroxymethyl-tetrahydro-pyran-3-ol

: 370886-87-6
((2R,3R,4S)-4-Benzyloxy-2-{3-[(2R,4R,4aS,6R,7R,8aR)-7-benzyloxy-6-benzyloxymethyl-4-(4-methoxy-benzyloxy)-octahydro-pyrano[3,2-b]pyran-2-yl]-prop-2-ynyl}-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 2,6-lutidine / CH₂Cl₂ / -78 °C

2: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

3: 100 percent / K₂CO₃ / methanol / 20 °C

4: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

5: Et₃SiH; BF₃*OEt₂ / CH₂Cl₂ / -30 °C

With 2,6-dimethylpyridine; triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; potassium carbonate; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/S0040-4039(01)01067-X