N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylvaline benzyl ester

Base Information

• Chemical Name: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylvaline benzyl ester
• CAS No.: 270085-16-0
• Molecular Formula: C₃₅H₄₂N₂O₅
• Molecular Weight: 570.729
• Mol file: 270085-16-0.mol

Synonyms:N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylvaline benzyl ester

Chemical Property of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylvaline benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylvaline benzyl ester

There total 2 articles about N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylvaline benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.4%

N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-leucine (103478-62-2) + benzyl (2S)-3-methyl-2-(methylamino)butanoate hydrochloride (89536-89-0) → N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylvaline benzyl ester (270085-16-0)

Guidance literature:

With 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -10 - 20 ℃;

DOI:10.1246/cl.2000.204

Reference yield: 91.0%

N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-leucine (103478-62-2) + MeVal-OBzl*TFA → N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylvaline benzyl ester (270085-16-0)

Guidance literature:

With 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/S0040-4020(00)00657-8

Reference yield:

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylvaline benzyl ester (270085-16-0) → H-MeLeu-MeVal-OBzl (89537-00-8)

Guidance literature:

With diethylamine; In acetonitrile;

DOI:10.1016/S0040-4020(00)00657-8

upstream raw materials:

N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-leucine

benzyl (2S)-3-methyl-2-(methylamino)butanoate hydrochloride

Downstream raw materials:

H-MeLeu-MeVal-OBzl

H-MeLeu-MeLeu-MeVal-OBzl

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylleucyl-N-methylvaline benzyl ester