N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylleucyl-N-methylvaline benzyl ester

Base Information

Chemical Name:N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylleucyl-N-methylvaline benzyl ester
CAS No.:270085-18-2
Molecular Formula:C₄₂H₅₅N₃O₆
Molecular Weight:697.915
Hs Code.:

Synonyms:N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylleucyl-N-methylvaline benzyl ester

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Chemical Property of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylleucyl-N-methylvaline benzyl ester

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Technology Process of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylleucyl-N-methylvaline benzyl ester

There total 5 articles about N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylleucyl-N-methylvaline benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.1%

: 103478-62-2
N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-leucine

: H-MeLeu-MeVal-OBzl*HCl

: 270085-18-2
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylleucyl-N-methylvaline benzyl ester

Guidance literature:: With 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -10 - 20 ℃;
DOI:10.1246/cl.2000.204

Reference yield: 48.0%

: 103478-62-2
N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-leucine

: 89537-00-8
H-MeLeu-MeVal-OBzl

: 270085-18-2
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylleucyl-N-methylvaline benzyl ester

Guidance literature:: With 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/S0040-4020(00)00657-8

Reference yield:

: 103478-62-2
N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-leucine

: 270085-18-2
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylleucyl-N-methylleucyl-N-methylvaline benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / 2-bromo-1-ethylpyridinium tetrafluoroborate; DIEA / CH₂Cl₂ / 1 h / 20 °C

2: Et₂NH / acetonitrile

3: 48 percent / 2-bromo-1-ethylpyridinium tetrafluoroborate; DIEA / CH₂Cl₂ / 4 h / 20 °C

With 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile; 1: Acylation / 2: Substitution / 3: Acylation;
DOI:10.1016/S0040-4020(00)00657-8