N⁽²⁾-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phthalimidooxymethyl)guanosine

Base Information

• Chemical Name: N⁽²⁾-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phthalimidooxymethyl)guanosine
• CAS No.: 1369323-62-5
• Molecular Formula: C₃₉H₅₀N₆O₁₁Si₂
• Molecular Weight: 835.031

Synonyms:N⁽²⁾-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phthalimidooxymethyl)guanosine

Chemical Property of N⁽²⁾-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phthalimidooxymethyl)guanosine

Chemical Property:

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Technology Process of N⁽²⁾-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phthalimidooxymethyl)guanosine

There total 4 articles about N⁽²⁾-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phthalimidooxymethyl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

→ N(2)-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phthalimidooxymethyl)guanosine (1369323-62-5)

Guidance literature:

Reference yield:

N-hydroxyphthalimide (524-38-9) + C31H46ClN5O8Si2 → N(2)-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phthalimidooxymethyl)guanosine (1369323-62-5)

Guidance literature:

N-hydroxyphthalimide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; for 0.166667h;

C₃₁H₄₆ClN₅O₈Si₂; In dichloromethane; at 25 ℃; for 24h;

DOI:10.1093/nar/gkr896

Reference yield:

N(2)-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-(methylthiomethyl)guanosine (1180489-71-7) → N(2)-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phthalimidooxymethyl)guanosine (1369323-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuryl dichloride / dichloromethane / 2 h / 25 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.17 h

2.2: 24 h / 25 °C

With sulfuryl dichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane;

DOI:10.1093/nar/gkr896

upstream raw materials:

N⁽²⁾-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-(methylthiomethyl)guanosine

N-hydroxyphthalimide

N²-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine

Downstream raw materials:

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