(R)-2-chloro-N-(4-nitrobenzyl)-N-(1-phenylethyl)acetamide

Base Information

• Chemical Name: (R)-2-chloro-N-(4-nitrobenzyl)-N-(1-phenylethyl)acetamide
• CAS No.: 1628434-24-1
• Molecular Formula: C₁₇H₁₇ClN₂O₃
• Molecular Weight: 332.787
• Mol file: 1628434-24-1.mol

Synonyms:(R)-2-chloro-N-(4-nitrobenzyl)-N-(1-phenylethyl)acetamide

Chemical Property of (R)-2-chloro-N-(4-nitrobenzyl)-N-(1-phenylethyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (R)-2-chloro-N-(4-nitrobenzyl)-N-(1-phenylethyl)acetamide

There total 1 articles about (R)-2-chloro-N-(4-nitrobenzyl)-N-(1-phenylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N-(4-nitrobenzyl)-1-phenylethanamine (1379442-59-7) + chloroacetyl chloride (79-04-9) → (R)-2-chloro-N-(4-nitrobenzyl)-N-(1-phenylethyl)acetamide (1628434-24-1)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 3.5h; Inert atmosphere;

DOI:10.1002/anie.201405508

Reference yield: 74.0%

(R)-2-chloro-N-(4-nitrobenzyl)-N-(1-phenylethyl)acetamide (1628434-24-1) → (S)-4-(4-nitrophenyl)-1-((R)-1-phenylethyl)azetidin-2-one (1628434-44-5)

Guidance literature:

With 1-Adamantanecarboxylic acid; C₇₁H₁₀₈NO₈P; caesium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 110 ℃; enantioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201405508

Reference yield:

(R)-2-chloro-N-(4-nitrobenzyl)-N-(1-phenylethyl)acetamide (1628434-24-1) → (S)-4-(4-nitrophenyl)-1-((R)-1-phenylethyl)azetidin-2-one (1628434-44-5) + (R)-4-(4-nitrophenyl)-1-((R)-1-phenylethyl)azetidin-2-one (1628434-49-0)

Guidance literature:

With 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; 1-Adamantanecarboxylic acid; caesium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 110 ℃; Overall yield = 47 %; enantioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201405508

upstream raw materials:

(R)-N-(4-nitrobenzyl)-1-phenylethanamine

chloroacetyl chloride

Downstream raw materials:

(S)-4-(4-nitrophenyl)-1-((R)-1-phenylethyl)azetidin-2-one

(R)-4-(4-nitrophenyl)-1-((R)-1-phenylethyl)azetidin-2-one