trans 2-fluoro-4-tert-butyl cyclohexanone

Base Information

• Chemical Name: trans 2-fluoro-4-tert-butyl cyclohexanone
• CAS No.: 1544-02-1
• Molecular Formula: C₁₀H₁₇FO
• Molecular Weight: 172.243
• Mol file: 1544-02-1.mol

Synonyms:trans 2-fluoro-4-tert-butyl cyclohexanone

Chemical Property of trans 2-fluoro-4-tert-butyl cyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of trans 2-fluoro-4-tert-butyl cyclohexanone

There total 27 articles about trans 2-fluoro-4-tert-butyl cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(4-(tert-butyl)cyclohex-1-en-1-yl)acetamide (135663-21-7) → trans 2-fluoro-4-tert-butyl cyclohexanone (1544-02-1)

Guidance literature:

With N-fluoropyridinium pyridine heptafluorodiborate; In acetonitrile; at 25 ℃; for 48h;

DOI:10.1021/jo00020a051

Reference yield: 74.0%

1-acetoxy-4-tert-butylcyclohexene (7360-39-6) → trans 2-fluoro-4-tert-butyl cyclohexanone (1544-02-1)

Guidance literature:

With 1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2,2,2]octane-1,4-bis(tetrafluoroborate); In acetonitrile; at 20 ℃;

DOI:10.1016/S0040-4039(99)00303-2

Reference yield: 44.0%

4-t-butyl-1-trimethylsilyloxy-1-cyclohexene (19980-19-9) → trans 2-fluoro-4-tert-butyl cyclohexanone (1544-02-1)

Guidance literature:

With 1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2,2,2]octane-1,4-bis(tetrafluoroborate); In acetonitrile; at 20 ℃;

DOI:10.1016/S0040-4039(99)00303-2

upstream raw materials:

1-acetoxy-4-tert-butylcyclohexene

N-(4-(tert-butyl)cyclohex-1-en-1-yl)acetamide

4-t-butyl-1-trimethylsilyloxy-1-cyclohexene

1-ethoxy-4-tert-butylcyclohexene

Downstream raw materials:

trans-2α-fluoro-4-t-butylcyclohexanone

2t-Fluor-4c-tert.-butyl-1r-cyclohexanol

2c-Fluor-4c-tert.-butyl-1r-cyclohexanol

2t-Fluor-4t-tert.-butyl-1r-cyclohexanol

Refernces

• 1、 Dal Poggetto, Guilherme,Soares, Jo?o Vitor,Tormena, Cláudio F.. "Selective Nuclear Magnetic Resonance Experiments for Sign-Sensitive Determination of Heteronuclear Couplings: Expanding the Analysis of Crude Reaction Mixtures". . p. 14047 - 14053. Retrieved 2020.
• 2、 Zajc, Barbara,Zupan, Marko. "Fluorination with Xenon Difluoride. 27. The Effect of Catalyst on Fluorination of 1,3-Diketones and Enol Acetates". . p. 573 - 575. Retrieved 1982.
• 3、 Sato, Saeko,Yoshida, Masanori,Hara, Shoji. "Fluorination of ketones using iodotoluene difluoride". . p. 2602 - 2605. Retrieved 2005.
• 4、 Stavber, Gaj,Zupan, Marko,Stavber, Stojan. "Micellar-system-mediated direct fluorination of ketones in water". scheme or table. p. 589 - 594. Retrieved 2009/07/09.