2S,5S,6R-2-carbethoxymethyl-4,5-dimethyl-6-phenyl-morpholin-3-one

Base Information

• Chemical Name: 2S,5S,6R-2-carbethoxymethyl-4,5-dimethyl-6-phenyl-morpholin-3-one
• CAS No.: 497157-61-6
• Molecular Formula: C₁₆H₂₁NO₄
• Molecular Weight: 291.347
• Mol file: 497157-61-6.mol

Synonyms:2S,5S,6R-2-carbethoxymethyl-4,5-dimethyl-6-phenyl-morpholin-3-one

Chemical Property of 2S,5S,6R-2-carbethoxymethyl-4,5-dimethyl-6-phenyl-morpholin-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2S,5S,6R-2-carbethoxymethyl-4,5-dimethyl-6-phenyl-morpholin-3-one

There total 3 articles about 2S,5S,6R-2-carbethoxymethyl-4,5-dimethyl-6-phenyl-morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl (Z)-2-((5S,6R)-4,5-dimethyl-3-oxo-6-phenylmorpholin-2-ylidene)acetate (497157-60-5) → 2S,5S,6R-2-carbethoxymethyl-4,5-dimethyl-6-phenyl-morpholin-3-one (497157-61-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 12h; under 760 Torr;

DOI:10.1016/S0040-4020(02)01151-1

Reference yield:

ephedrine hydrochloride (50-98-6) → 2S,5S,6R-2-carbethoxymethyl-4,5-dimethyl-6-phenyl-morpholin-3-one (497157-61-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / 4-(dimethylamino)pyridine; Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 80 percent / CH₂Cl₂ / 48 h / 20 °C

3: 100 percent / H₂ / 5 percent Pd/C / ethyl acetate / 12 h / 760 Torr

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; 2: Wittig reaction;

DOI:10.1016/S0040-4020(02)01151-1

Reference yield:

(5S,6R)-4,5-dimethyl-6-phenyl-morpholin-2,3-dione (78927-93-2) → 2S,5S,6R-2-carbethoxymethyl-4,5-dimethyl-6-phenyl-morpholin-3-one (497157-61-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / CH₂Cl₂ / 48 h / 20 °C

2: 100 percent / H₂ / 5 percent Pd/C / ethyl acetate / 12 h / 760 Torr

With hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate; 1: Wittig reaction;

DOI:10.1016/S0040-4020(02)01151-1

upstream raw materials:

ethyl (Z)-2-((5S,6R)-4,5-dimethyl-3-oxo-6-phenylmorpholin-2-ylidene)acetate

ephedrine hydrochloride

(5S,6R)-4,5-dimethyl-6-phenyl-morpholin-2,3-dione

Downstream raw materials:

2S,5S,6R-2-(2-hydroxy-2-methyl-propyl)-4,5-dimethyl-6-phenyl-morpholin-3-one

((2S,5S,6R)-4,5-Dimethyl-3-oxo-6-phenyl-morpholin-2-yl)-acetic acid

2-Allyl-2-((2S,5S,6R)-4,5-dimethyl-3-oxo-6-phenyl-morpholin-2-yl)-pent-4-enoic acid ethyl ester

2-((2S,5S,6R)-4,5-Dimethyl-3-oxo-6-phenyl-morpholin-2-yl)-2-ethyl-butyric acid ethyl ester