Ephedrine hydrochloride

Base Information Edit

Chemical Name:Ephedrine hydrochloride
CAS No.:50-98-6
Deprecated CAS:14992-57-5,15826-51-4,7060-73-3,877-36-1,15826-51-4,7060-73-3,877-36-1
Molecular Formula:C10H15NO^.HCl
Molecular Weight:201.696
Hs Code.:29394100
European Community (EC) Number:200-074-6,205-153-9
UNII:NLJ6390P1Z
DSSTox Substance ID:DTXSID1045825
Wikidata:Q27284939
NCI Thesaurus Code:C75031
RXCUI:91165
ChEMBL ID:CHEMBL2146102
Mol file:50-98-6.mol

Synonyms:Ephedrine;Ephedrine Erythro Isomer;Ephedrine Hydrochloride;Ephedrine Renaudin;Ephedrine Sulfate;Erythro Isomer of Ephedrine;Hydrochloride, Ephedrine;Renaudin, Ephedrine;Sal Phedrine;Sal-Phedrine;SalPhedrine;Sulfate, Ephedrine

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Ephedrine hydrochloride Edit

Chemical Property:

Appearance/Colour:colourless crystals or white crystalline powder
Vapor Pressure:0.00865mmHg at 25°C
Melting Point:216-220 °C(lit.)
Boiling Point:255 °C at 760 mmHg
Flash Point:85.6 °C
PSA：32.26000
LogP:2.52080
Storage Temp.:2-8°C
Solubility.:Freely soluble in water, soluble in ethanol (96 per cent).
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:201.0920418
Heavy Atom Count:13
Complexity:121

Purity/Quality:

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn,T,F
Statements: 22-39/23/24/25-23/24/25-11
Safety Statements: 22-23-25-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C(C1=CC=CC=C1)O)NC.Cl
Isomeric SMILES:C[C@@H]([C@@H](C1=CC=CC=C1)O)NC.Cl
Recent ClinicalTrials:Influence of a Bolus Administration of Ephedrine and Phenylephrine on the Spinal Oxygen Saturation, Measured With NIRS.
Recent EU Clinical Trials:Comparison of the efficacy of ephedrine versus norepinephrine in the treatment of hypotension occurring after induction of general anesthesia in patients with chronic renal failure: randomized double-blind pilot study
Uses antidyskinetic

Technology Process of Ephedrine hydrochloride

There total 18 articles about Ephedrine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1798-60-3
(R)-1-hydroxy-1-phenyl-2-propanone

: 74-89-5
methylamine

: 50-98-6
ephedrine hydrochloride

Guidance literature:: (R)-1-hydroxy-1-phenyl-2-propanone; methylamine; With 5%-palladium/activated carbon; hydrogen; In water; toluene; at 30 - 55 ℃; under 1500.15 - 3000.3 Torr;

With hydrogenchloride; In water; toluene; pH=2;

Reference yield: 52.0%

: 150085-16-8
(3S,4S,5S,6S,2'S,4'S,5'R)-2-benzyloxycarbonyl-4,5-dihydroxy-6-(3,4-dimethyl-5-phenyloxazolidin-2-yl)-3-methyl-3,4,5,6-tetrahydro-1,2-oxazine

: 50-98-6
ephedrine hydrochloride

: 150085-57-7,449729-69-5,528593-83-1
(2S,3S,4R,5R)-2-methyl-3,4,5-trihydroxypiperidine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 25h; under 1500.1 Torr; Ambient temperature;
DOI:10.1016/S0040-4020(01)86312-2