C₂₀H₂₀ClNO₃

Base Information

• Chemical Name: C₂₀H₂₀ClNO₃
• CAS No.: 1575517-19-9
• Molecular Formula: C₂₀H₂₀ClNO₃
• Molecular Weight: 357.837
• Mol file: 1575517-19-9.mol

Synonyms:C₂₀H₂₀ClNO₃

Chemical Property of C₂₀H₂₀ClNO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₀ClNO₃

There total 4 articles about C₂₀H₂₀ClNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-tributylstannyl-3-chloropropene (155509-51-6,155197-78-7,351336-76-0) + C19H22N2O4 (1575517-66-6) → C20H20ClNO3 (1575517-19-9)

Guidance literature:

With methyllithium lithium bromide; at -78 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2014.02.033

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → C20H20ClNO3 (1575517-19-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / Reflux; Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: trimethylaluminum / dichloromethane / Inert atmosphere

3.1: methyllithium lithium bromide / -78 °C / Inert atmosphere

With thionyl chloride; methyllithium lithium bromide; trimethylaluminum; In dichloromethane;

DOI:10.1016/j.tet.2014.02.033

Reference yield:

(S)-4-methoxy-N-benzoyl-phenylalanine-methylester (18217-57-7) → C20H20ClNO3 (1575517-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylaluminum / dichloromethane / Inert atmosphere

2: methyllithium lithium bromide / -78 °C / Inert atmosphere

With methyllithium lithium bromide; trimethylaluminum; In dichloromethane;

DOI:10.1016/j.tet.2014.02.033

upstream raw materials:

L-tyrosine

(S)-4-methoxy-N-benzoyl-phenylalanine-methylester

benzoyl chloride

1-tributylstannyl-3-chloropropene

Downstream raw materials:

C₂₀H₂₂ClNO₃