(4R)-4-{[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]methyl}-2,2-dimethyl-1,3-dioxolane

Base Information

Chemical Name:(4R)-4-{[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]methyl}-2,2-dimethyl-1,3-dioxolane
CAS No.:890749-79-8
Molecular Formula:C₂₁H₂₂FN₃O₂
Molecular Weight:367.423
Hs Code.:

Synonyms:(4R)-4-{[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]methyl}-2,2-dimethyl-1,3-dioxolane

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Chemical Property of (4R)-4-{[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]methyl}-2,2-dimethyl-1,3-dioxolane

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Technology Process of (4R)-4-{[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]methyl}-2,2-dimethyl-1,3-dioxolane

There total 4 articles about (4R)-4-{[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]methyl}-2,2-dimethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 890749-72-1
(10R,11R)-11-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-8-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol

: 890749-79-8
(4R)-4-{[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]methyl}-2,2-dimethyl-1,3-dioxolane

: 791-28-6
Triphenylphosphine oxide

Guidance literature:: (10R,11R)-11-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-8-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -30 ℃; for 0.333333h;

With diphenyl phosphoryl azide; In tetrahydrofuran; at -30 - 20 ℃;

Reference yield:

: 890749-72-1
(10R,11R)-11-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-8-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol

: 26386-88-9
diphenyl phosphoryl azide

: 890749-79-8
(4R)-4-{[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]methyl}-2,2-dimethyl-1,3-dioxolane

: 791-28-6
Triphenylphosphine oxide

Guidance literature:: (10R,11R)-11-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-8-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol; triphenylphosphine; With di-isopropyl azodicarboxylate; In tetrahydrofuran; at -30 ℃; for 0.333333h;

diphenyl phosphoryl azide; In tetrahydrofuran; at -30 - 20 ℃;

Reference yield:

: 887611-88-3
(11Z)-11-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-8-fluoro-5,11-dihydro-10H-dibenzo[a,d]cyclohepten-10-one

: 890749-79-8
(4R)-4-{[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]methyl}-2,2-dimethyl-1,3-dioxolane

: 791-28-6
Triphenylphosphine oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; triethylamine / palladium 10% on activated carbon / isopropyl alcohol / 6 h

1.2: 1 h / 40 °C

2.1: sodium tetrahydroborate / isopropyl alcohol / 1 h / 0 - 20 °C / pH 7 / Aqueous phosphate buffer

3.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.33 h / -30 °C

3.2: -30 - 20 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; isopropyl alcohol;