N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-benzenesulfinyl)-ethoxy]-9H-purin-2-yl}-isobutyramide

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Chemical Name:N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-benzenesulfinyl)-ethoxy]-9H-purin-2-yl}-isobutyramide
CAS No.:118088-99-6
Molecular Formula:C₂₂H₂₆N₆O₈S
Molecular Weight:534.55
Hs Code.:

Synonyms:N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-benzenesulfinyl)-ethoxy]-9H-purin-2-yl}-isobutyramide

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Chemical Property of N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-benzenesulfinyl)-ethoxy]-9H-purin-2-yl}-isobutyramide

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Technology Process of N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-benzenesulfinyl)-ethoxy]-9H-purin-2-yl}-isobutyramide

There total 3 articles about N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-benzenesulfinyl)-ethoxy]-9H-purin-2-yl}-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 82921-54-8
N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenylsulfanyl)-ethoxy]-9H-purin-2-yl}-isobutyramide

: 118088-99-6
N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-benzenesulfinyl)-ethoxy]-9H-purin-2-yl}-isobutyramide

Guidance literature:: With sodium periodate; In methanol; for 48h; Ambient temperature;
DOI:10.1016/S0968-0896(97)00164-8

Reference yield:

: 13287-76-8
2-(p-nitrophenylthio)ethanol

: 118088-99-6
N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-benzenesulfinyl)-ethoxy]-9H-purin-2-yl}-isobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) N-(trimethylsilyl)imidazole, 2.) Ph₃P, diethylazodicarboxylate, 3.) HF, pyridine

2: 94 percent / aq. NaIO₄ / methanol / 48 h / Ambient temperature

With pyridine; sodium periodate; hydrogen fluoride; 1-(Trimethylsilyl)imidazole; triphenylphosphine; diethylazodicarboxylate; In methanol;
DOI:10.1016/S0968-0896(97)00164-8

Reference yield:

: 1849-36-1
para-nitrobenzenethiol

: 118088-99-6
N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-benzenesulfinyl)-ethoxy]-9H-purin-2-yl}-isobutyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / aq. KOH / ethanol / 3 h / Heating

2: 1.) N-(trimethylsilyl)imidazole, 2.) Ph₃P, diethylazodicarboxylate, 3.) HF, pyridine

3: 94 percent / aq. NaIO₄ / methanol / 48 h / Ambient temperature

With pyridine; potassium hydroxide; sodium periodate; hydrogen fluoride; 1-(Trimethylsilyl)imidazole; triphenylphosphine; diethylazodicarboxylate; In methanol; ethanol;
DOI:10.1016/S0968-0896(97)00164-8