13287-76-8

Usage

Uses

Used in Organic Synthesis:
2-Hydroxyethyl 4-nitrophenyl sulfide is used as a building block in the synthesis of various chemical compounds, contributing to the creation of a wide range of organic molecules with diverse applications.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-Hydroxyethyl 4-nitrophenyl sulfide is utilized as a key intermediate in the production of drugs, playing a crucial role in the development of new medications.
Used in Chemical Reactions as a Reagent:
2-Hydroxyethyl 4-nitrophenyl sulfide is employed as a reagent in certain chemical reactions, facilitating specific transformations and processes in the synthesis of target molecules.
Used in Antimicrobial Applications:
2-Hydroxyethyl 4-nitrophenyl sulfide has been studied for its potential antimicrobial properties, making it a candidate for use in applications that require the inhibition of microbial growth, such as in the development of antimicrobial agents.
Used in Antioxidant Applications:
2-Hydroxyethyl 4-nitrophenyl sulfide's potential antioxidant properties suggest its use in applications that require protection against oxidative stress, such as in the formulation of health supplements or in the preservation of sensitive materials.

InChI:InChI=1/C8H9NO3S/c10-5-6-13-8-3-1-7(2-4-8)9(11)12/h1-4,10H,5-6H2

Upstream product

• 1849-36-1 para-nitrobenzenethiol 
• 107-07-3 2-chloro-ethanol 
• 100-05-0 4-nitrobenzenediazonium chloride 
• 60-24-2 2-hydroxyethanethiol 
• 75032-27-8 ethyl <(p-nitrophenyl)thio>acetate 
• 37482-11-4 sodium 2-mercaptoethanol 
• 100-00-5 4-chlorobenzonitrile 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 13113-79-6 sodium 4-nitrobenzenethiolate 
• 540-51-2 2-bromoethanol 
• 1892-29-1 bis(2-hydroxyethyl) disulfide 
• 100-01-6 4-nitro-aniline 
• 701-57-5 1-methylthio-4-nitro-benzene 

Downstream Products

• 6461-63-8 (2-chloro-ethyl)-(4-nitro-phenyl)-sulfone 
• 21386-32-3 p-nitrophenyl-β-hydroxyethylsulfone 
• 13290-29-4 (2-bromo-ethyl)-(4-nitro-phenyl)-sulfide 
• 19284-82-3 P-aminobenzene-β-hydroxyethyl sulfide 
• 5535-73-9 (2-chloro-ethyl)-(4-nitro-phenyl)-sulfide 
• 121-69-7 N,N-dimethyl-aniline 
• 125239-99-8 2-(4-nitrophenylthio)ethyl acetate 
• 20020-31-9 1-methanesulfonyloxy-2-(4-nitro-phenylsulfanyl)-ethane 
• 82921-54-8 N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenylsulfanyl)-ethoxy]-9H-purin-2-yl}-isobutyramide 
• 75032-22-3 (β-hydroxyethyl)methyl(p-nitrophenyl)sulfonium perchlorate 
• 47174-61-8 L-Leucin-<2-(4-nitrophenylmercapto)-ethylester> 
• 71532-94-0 C₁₅H₁₅NO₃S₂ 
• 916262-78-7 2-[(4-nitrophenyl)sulfanyl]ethyl N-(2-methyl-1-oxopropyl)-L-prolinate 
• 101265-97-8 N-<2-(4-nitrophenyl)sulfonyl>ethylpiperidine 

Relevant academic research and scientific papers

Transition-Metal-Free Aryl-Heteroatom Bond Formation via C-S Bond Cleavage

Aryl-heteroatom bonds (C-Het) are almost ubiquitously present in chemical molecules. However, methods for diverse C-Het bond formations from a simple substrate are limited. Herein, we report a convenient and efficient C-S bond transformation of aryl sulfoniums to various C-Het bonds (C-O, C-S, C-Sn, C-Si, C-Se) in the absence of any transition-metal catalyst. These reactions proceeded in mild conditions with a wide substrate scope.

DYE AND DYEING METHOD

A dyeing method is provided, which includes dyeing a dye to a fiber by a supercritical fluid, wherein the dye has a chemical structure of:R 1 is C1-6alkyl group, R 2 is C1-6alkyl group, each of R 3 is independently of H or C1-6alkyl group, and R 4 is a single bond or C1-6alkylene group. When R 4 is single bond, R 5 is. When R 4 is C1-6alkylene group, R 5 is H, Br, Cl, or. Each of R 6 is independently of H, Cl, Br, OCH3, or C1-6alkyl group.

Method for preparing p-aminophenyl-beta-hydroxyethyl sulfone sulfate

The invention discloses a method for preparing p-aminophenyl-beta-hydroxyethyl sulfone sulfate. The method comprises the following steps: with p-nitrochlorobenzene and mercaptoethanol as basic raw materials, adding into an N,N-dimethylformamide solvent, sufficiently dissolving and uniformly mixing to obtain p-nitrophenyl-beta-hydroxyethyl sulfide, then adding hydrogen peroxide, separating out an oxidization crystallization material, adding solvent water and a palladium-carbon catalyst into the oxidization crystallization material, reacting, filtering to obtain a hydrogenated product and the solvent water, adding the hydrogenated product into an ice-water mixture, diluting, adding pure sulfuric acid, stirring, heating to 150 DEG C, and performing an esterification reaction for 2-3h under avacuum condition to obtain the p-aminophenyl-beta-hydroxyethyl sulfone sulfate after the reaction. The product prepared by the method provided by the invention is high in purity and yield, the raw material consumption is low, the raw material utilization rate is increased, few byproducts are produced and are easy to separate, produced wastewater is easy to treat, and the environmental protection investment is low.

Preparing methods of p-aminophenyl-beta-hydroxyethylsulfonyl and p-minophenyl-beta-hydroxyethylsulfonyl sulphonate

The invention relates to preparing methods of p-aminophenyl-beta-hydroxyethylsulfonyl and p-minophenyl-beta-hydroxyethylsulfonyl sulphonate. The preparing methods both comprise the steps that p-aminophenyl-beta-hydroxyethylsulfonyl and hydrogen are used as raw materials, modified framework nickel is used as a hydrogen-adding catalyst, a catalytic hydrogenation reaction is conducted in a solvent toobtain reduction liquid, and modified framework nickel and the solvent in the reduction liquid are separated and removed to obtain p-minophenyl-beta-hydroxyethylsulfonyl sulphonate; according to modified framework nickel, nickel is used as a framework, and modified framework nickel is prepared from, by mass, 75-95 parts of Ni, 3-15 parts of Al and 2-10 parts of metal adjuvant; the metal adjuvantcomprises the combination of any one or at least two of Mo, Cu and Cr. The yield can reach 94% or above; preparation of p-minophenyl-beta-hydroxyethylsulfonyl sulphonate is a continuous production technology, the technology is simplified, the production efficiency is high, the quality is stable, the production cost is low, and the economic benefit and social benefit are obvious.

Ascorbic Acid Promoted Metal-Free Synthesis of Aryl Sulfides with Anilines Nitrosated in Situ by tert -Butyl Nitrite

A mild, metal-free synthesis of aryl sulfides has been disclosed. Aryl diazonium ion was generated by the in situ nitrosation of aniline, and it was reduced by ascorbic acid (vitamin C) to form aryl radical, which underwent a thiolation with disulfide to yield aryl sulfide. The reaction proceeded smoothly without heating or irradiation. This strategy was also expanded to the synthesis of aryl selenides.

Synthesis and evaluation of sulfonylethyl-containing phosphotriesters of 3′-azido-3′-deoxythymidine as anticancer prodrugs

A series of bis(sulfonylethyl) and mono(sulfonylethyl) phenyl phosphotriesters of zidovudine (3′-azido-3′-deoxythymidine, AZT) were synthesized as potential anticancer prodrugs that liberate AZT monophosphate via nonenzymatic β-elimination mechanism. Stab

Design, Synthesis, and Evaluation of 2-(arylsulfonyl)oxiranes as Cell-permeable Covalent Inhibitors of Protein Tyrosine Phosphatases

A structure-based design approach has been applied to develop 2-(arylsulfonyl)oxiranes as potential covalent inhibitors of protein tyrosine phosphatases. A detailed kinetic analysis of inactivation by these covalent inhibitors reveals that this class of compounds inhibits a panel of protein tyrosine phosphatases in a time- and dose-dependent manner, consistent with the covalent modification of the enzyme active site. An inactivation experiment in the presence of sodium arsenate, a known competitive inhibitor of protein tyrosine phosphatase, indicated that these inhibitors were active site bound. This finding is consistent with the mass spectrometric analysis of the covalently modified protein tyrosine phosphatase enzyme. Additional experiments indicated that these compounds remained inert toward other classes of arylphosphate-hydrolyzing enzymes, and alkaline and acid phosphatases. Cell-based experiments with human A549 lung cancer cell lines indicated that 2-(phenylsulfonyl)oxirane (1) caused an increase in intracellular pTyr levels in a dose-dependent manner thereby suggesting its cell-permeable nature. Taken together, the newly identified 2-(arylsulfonyl)oxiranyl moiety could serve as a novel chemotype for the development of activity-based probes and therapeutic agents against protein tyrosine phosphatase superfamily of enzymes.

Synthesis and second-order nonlinearities of chiral prolinol-substituted chromophores

A new series of thiophene- and furan-containing chromophores with a chiral prolinol donor and a sulfone acceptor has been synthesized. The UV-vis absorptions, second-order nonlinear optical properties, and X-ray crystal structures are described.

BENZAZEPINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

The present invention provides a novel benzazepine derivative represented by formula : wherein, R1 is a 5- or 6-membered aromatic ring, R2 is lower alkyl group, etc., Y is an optionally substituted imino group, ring A and ring B are independently an optionally substituted aromatic ring, W is formula -W1-X2-W2- (W1 and W2 are independently S(O)m1 (m1 is 0, 1 or 2), etc., and X2 is an optionally substituted alkylene groupetc. ), a preparation method and use thereof.

π-deficient 2-(arylsulfonyl)ethyl esters as protecting groups for carboxylic acids

Several π-deficient 2-(arylsulfonyl)ethyl groups have been studied as carboxylic acid protecting groups. The 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl group is the most easily removed protecting group for acids under mild basic conditions using aqueous NaHCO3.