13287-76-8

Basic information

• Product Name: 2-HYDROXYETHYL 4-NITROPHENYL SULFIDE
• Synonyms: 2-HYDROXYETHYL 4-NITROPHENYL SULFIDE;2-[(4-Nitrophenyl)sulfanyl]ethanol;2-(4-Nitrophenylthio)ethanol;2-(p-Nitrophenylthio)ethanol
• CAS NO: 13287-76-8
• Molecular Formula: C₈H₉NO₃S
• Molecular Weight: 199.23
• Mol File: 13287-76-8.mol
• Article Data: 17

Chemical Properties

• Melting Point: 60 °C
• Boiling Point: 370.2 °C at 760 mmHg
• Flash Point: 177.7 °C
• Appearance: /
• Density: 1.35 g/cm³
• Vapor Pressure: 3.92E-06mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: 2-8°C
• PKA: 14.25±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXYETHYL 4-NITROPHENYL SULFIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXYETHYL 4-NITROPHENYL SULFIDE(13287-76-8)
• EPA Substance Registry System: 2-HYDROXYETHYL 4-NITROPHENYL SULFIDE(13287-76-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT, IRRITANT-HARMFUL, STEN
• Hazardous Substances Data: 13287-76-8(Hazardous Substances Data)

Usage

General Description

2-Hydroxyethyl 4-nitrophenyl sulfide is an organic compound with the chemical formula C8H9NO4S. It is a nitrophenyl sulfide derivative with a 2-hydroxyethyl group attached to the sulfur atom. 2-Hydroxyethyl 4-nitrophenyl sulfide is commonly used in organic synthesis and in the production of pharmaceuticals. It has potential applications as a building block in the synthesis of various chemical compounds and as a reagent in some chemical reactions. Additionally, 2-Hydroxyethyl 4-nitrophenyl sulfide has been studied for its potential biological activity, including its antimicrobial and antioxidant properties.

InChI:InChI=1/C8H9NO3S/c10-5-6-13-8-3-1-7(2-4-8)9(11)12/h1-4,10H,5-6H2

Upstream product

• 37482-11-4 sodium 2-mercaptoethanol 
• 100-00-5 4-chlorobenzonitrile 
• 60-24-2 2-hydroxyethanethiol 
• 1849-36-1 para-nitrobenzenethiol 
• 1892-29-1 bis(2-hydroxyethyl) disulfide 
• 100-01-6 4-nitro-aniline 
• 701-57-5 1-methylthio-4-nitro-benzene 
• 540-51-2 2-bromoethanol 
• 13113-79-6 sodium 4-nitrobenzenethiolate 
• 107-07-3 2-chloro-ethanol 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 75032-27-8 ethyl <(p-nitrophenyl)thio>acetate 
• 100-05-0 4-nitrobenzenediazonium chloride 

Downstream Products

• 20020-31-9 1-methanesulfonyloxy-2-(4-nitro-phenylsulfanyl)-ethane 
• 46843-04-3 Glycin-<2-(4-nitrophenylmercapto)-ethylester> 
• 21386-32-3 p-nitrophenyl-β-hydroxyethylsulfone 
• 125239-99-8 2-(4-nitrophenylthio)ethyl acetate 
• 2494-89-5 2-(p-aminophenylsulfonyl)ethyl hydrogen sulfate 
• 83451-93-8 2-(4-nitro-benzenesulfinyl)-ethanol 
• 20020-37-5 1-methanesulfonyloxy-2-(4-nitro-benzenesulfonyl)-ethane 
• 102093-86-7 O⁴-(4-nitrophenylsulfonylethyl)thymidine 
• 102093-87-8 O⁴-(4-nitrophenylsulfonylethyl)uridine 
• 122895-46-9 (2S,3R)-3-Benzyloxy-2-tert-butoxycarbonylamino-butyric acid 2-(4-phenylazo-benzenesulfonyl)-ethyl ester 
• 122895-45-8 (S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionic acid 2-(4-phenylazo-benzenesulfonyl)-ethyl ester 
• 122895-47-0 (S)-2-tert-Butoxycarbonylamino-3-phenyl-propionic acid 2-(4-phenylazo-benzenesulfonyl)-ethyl ester 
• 122895-44-7 tert-Butoxycarbonylamino-acetic acid 2-(4-phenylazo-benzenesulfonyl)-ethyl ester 
• 73976-76-8 2-<4-(phenylazo)phenylsulfonyl>ethanol 

Relevant articles and documents

DYE AND DYEING METHOD

A dyeing method is provided, which includes dyeing a dye to a fiber by a supercritical fluid, wherein the dye has a chemical structure of:R 1 is C1-6alkyl group, R 2 is C1-6alkyl group, each of R 3 is independently of H or C1-6alkyl group, and R 4 is a single bond or C1-6alkylene group. When R 4 is single bond, R 5 is. When R 4 is C1-6alkylene group, R 5 is H, Br, Cl, or. Each of R 6 is independently of H, Cl, Br, OCH3, or C1-6alkyl group.

Method for preparing p-aminophenyl-beta-hydroxyethyl sulfone sulfate

The invention discloses a method for preparing p-aminophenyl-beta-hydroxyethyl sulfone sulfate. The method comprises the following steps: with p-nitrochlorobenzene and mercaptoethanol as basic raw materials, adding into an N,N-dimethylformamide solvent, sufficiently dissolving and uniformly mixing to obtain p-nitrophenyl-beta-hydroxyethyl sulfide, then adding hydrogen peroxide, separating out an oxidization crystallization material, adding solvent water and a palladium-carbon catalyst into the oxidization crystallization material, reacting, filtering to obtain a hydrogenated product and the solvent water, adding the hydrogenated product into an ice-water mixture, diluting, adding pure sulfuric acid, stirring, heating to 150 DEG C, and performing an esterification reaction for 2-3h under avacuum condition to obtain the p-aminophenyl-beta-hydroxyethyl sulfone sulfate after the reaction. The product prepared by the method provided by the invention is high in purity and yield, the raw material consumption is low, the raw material utilization rate is increased, few byproducts are produced and are easy to separate, produced wastewater is easy to treat, and the environmental protection investment is low.

Ascorbic Acid Promoted Metal-Free Synthesis of Aryl Sulfides with Anilines Nitrosated in Situ by tert -Butyl Nitrite

A mild, metal-free synthesis of aryl sulfides has been disclosed. Aryl diazonium ion was generated by the in situ nitrosation of aniline, and it was reduced by ascorbic acid (vitamin C) to form aryl radical, which underwent a thiolation with disulfide to yield aryl sulfide. The reaction proceeded smoothly without heating or irradiation. This strategy was also expanded to the synthesis of aryl selenides.