5-(4-hydroxymethyl-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl)thiophene-2-carbonitrile

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Chemical Name:5-(4-hydroxymethyl-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl)thiophene-2-carbonitrile
CAS No.:1401226-56-9
Molecular Formula:C₁₆H₁₃N₃O₃S
Molecular Weight:327.364
Hs Code.:

Synonyms:5-(4-hydroxymethyl-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl)thiophene-2-carbonitrile

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Chemical Property of 5-(4-hydroxymethyl-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl)thiophene-2-carbonitrile

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Technology Process of 5-(4-hydroxymethyl-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl)thiophene-2-carbonitrile

There total 4 articles about 5-(4-hydroxymethyl-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl)thiophene-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1401226-53-6
5-[4-(tert-butyldimethylsilanyloxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]thiophene-2-carbonitrile

: 1401226-56-9
5-(4-hydroxymethyl-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl)thiophene-2-carbonitrile

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1021/jm300281x

Reference yield:

: 2160-62-5
5-bromo-2-thiophenecarbonitrile

: 1401226-56-9
5-(4-hydroxymethyl-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl)thiophene-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: copper(I) oxide / N,N-dimethyl acetamide / 0.83 h / 160 °C / Microwave irradiation; Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 48 h / 20 °C / Inert atmosphere

With copper(I) oxide; hydrogenchloride; potassium carbonate; In 1,4-dioxane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm300281x

Reference yield:

: 1401226-50-3
5-[4-(tert-butyldimethylsilanyloxymethyl)-2,5-dioxo-4-phenylimidazolidin-1-yl]thiophene-2-carbonitrile

: 1401226-56-9
5-(4-hydroxymethyl-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl)thiophene-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 48 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm300281x