5-[4-(tert-butyldimethylsilanyloxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]thiophene-2-carbonitrile

Base Information

Chemical Name:5-[4-(tert-butyldimethylsilanyloxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]thiophene-2-carbonitrile
CAS No.:1401226-53-6
Molecular Formula:C₂₂H₂₇N₃O₃SSi
Molecular Weight:441.626
Hs Code.:

Synonyms:5-[4-(tert-butyldimethylsilanyloxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]thiophene-2-carbonitrile

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Chemical Property of 5-[4-(tert-butyldimethylsilanyloxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]thiophene-2-carbonitrile

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Technology Process of 5-[4-(tert-butyldimethylsilanyloxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]thiophene-2-carbonitrile

There total 3 articles about 5-[4-(tert-butyldimethylsilanyloxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]thiophene-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1401226-50-3
5-[4-(tert-butyldimethylsilanyloxymethyl)-2,5-dioxo-4-phenylimidazolidin-1-yl]thiophene-2-carbonitrile

: 74-88-4
methyl iodide

: 1401226-53-6
5-[4-(tert-butyldimethylsilanyloxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]thiophene-2-carbonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jm300281x

Reference yield:

: 2160-62-5
5-bromo-2-thiophenecarbonitrile

: 1401226-53-6
5-[4-(tert-butyldimethylsilanyloxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]thiophene-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: copper(I) oxide / N,N-dimethyl acetamide / 0.83 h / 160 °C / Microwave irradiation; Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With copper(I) oxide; potassium carbonate; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm300281x

Reference yield:

: 1401226-49-0
5-(tert-butyldimethylsilanyloxymethyl)-5-phenylimidazolidine-2,4-dione

: 1401226-53-6
5-[4-(tert-butyldimethylsilanyloxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]thiophene-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: copper(I) oxide / N,N-dimethyl acetamide / 0.83 h / 160 °C / Microwave irradiation; Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With copper(I) oxide; potassium carbonate; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm300281x