ethyl (E)-3-[5,6-bis-([1,1'-biphenyl]-4-ylmethoxy)-3-(4-chlorophenoxy)benzo[b]thiophen-2-yl]-2-(4-pyridyl)-2-propenoate

Base Information

• Chemical Name: ethyl (E)-3-[5,6-bis-([1,1'-biphenyl]-4-ylmethoxy)-3-(4-chlorophenoxy)benzo[b]thiophen-2-yl]-2-(4-pyridyl)-2-propenoate
• CAS No.: 334720-01-3
• Molecular Formula: C₅₀H₃₈ClNO₅S
• Molecular Weight: 800.374
• Mol file: 334720-01-3.mol

Synonyms:ethyl (E)-3-[5,6-bis-([1,1'-biphenyl]-4-ylmethoxy)-3-(4-chlorophenoxy)benzo[b]thiophen-2-yl]-2-(4-pyridyl)-2-propenoate

Chemical Property of ethyl (E)-3-[5,6-bis-([1,1'-biphenyl]-4-ylmethoxy)-3-(4-chlorophenoxy)benzo[b]thiophen-2-yl]-2-(4-pyridyl)-2-propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (E)-3-[5,6-bis-([1,1'-biphenyl]-4-ylmethoxy)-3-(4-chlorophenoxy)benzo[b]thiophen-2-yl]-2-(4-pyridyl)-2-propenoate

There total 8 articles about ethyl (E)-3-[5,6-bis-([1,1'-biphenyl]-4-ylmethoxy)-3-(4-chlorophenoxy)benzo[b]thiophen-2-yl]-2-(4-pyridyl)-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-5,6-methylenedioxybenzothiophene-2-carbonyl chloride (137278-46-7) → ethyl (E)-3-[5,6-bis-([1,1'-biphenyl]-4-ylmethoxy)-3-(4-chlorophenoxy)benzo[b]thiophen-2-yl]-2-(4-pyridyl)-2-propenoate (334720-01-3)

Guidance literature:

Multi-step reaction with 7 steps

1: toluene

2: BBr₃ / CH₂Cl₂

3: K₂CO₃ / dimethylformamide

4: LiAlH₄ / tetrahydrofuran

5: MnO₂ / toluene

6: NaH / dimethylformamide

7: Ac₂O

With manganese(IV) oxide; lithium aluminium tetrahydride; acetic anhydride; boron tribromide; sodium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 7: Knoevenagel reaction;

DOI:10.1016/S0960-894X(03)00233-6

Reference yield:

methyl 7-chloro-1,3-dioxa-5-thia-s-indacene-6-carboxylate (478400-02-1) → ethyl (E)-3-[5,6-bis-([1,1'-biphenyl]-4-ylmethoxy)-3-(4-chlorophenoxy)benzo[b]thiophen-2-yl]-2-(4-pyridyl)-2-propenoate (334720-01-3)

Guidance literature:

Multi-step reaction with 6 steps

1: BBr₃ / CH₂Cl₂

2: K₂CO₃ / dimethylformamide

3: LiAlH₄ / tetrahydrofuran

4: MnO₂ / toluene

5: NaH / dimethylformamide

6: Ac₂O

With manganese(IV) oxide; lithium aluminium tetrahydride; acetic anhydride; boron tribromide; sodium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 6: Knoevenagel reaction;

DOI:10.1016/S0960-894X(03)00233-6

Reference yield:

3-chloro-5,6-dihydroxy-benzo[b]thiophene-2-carboxylic acid methyl ester (591742-16-4) → ethyl (E)-3-[5,6-bis-([1,1'-biphenyl]-4-ylmethoxy)-3-(4-chlorophenoxy)benzo[b]thiophen-2-yl]-2-(4-pyridyl)-2-propenoate (334720-01-3)

Guidance literature:

Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide

2: LiAlH₄ / tetrahydrofuran

3: MnO₂ / toluene

4: NaH / dimethylformamide

5: Ac₂O

With manganese(IV) oxide; lithium aluminium tetrahydride; acetic anhydride; sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 5: Knoevenagel reaction;

DOI:10.1016/S0960-894X(03)00233-6

upstream raw materials:

pyridin-4-yl-acetic acid ethyl ester

5,6-bis-(biphenyl-4-ylmethoxy)-3-(4-chloro-phenoxy)-benzo[b]thiophene-2-carbaldehyde

3-chloro-5,6-methylenedioxybenzothiophene-2-carbonyl chloride

methyl 7-chloro-1,3-dioxa-5-thia-s-indacene-6-carboxylate