1,4-DI(2-PYRIDYL)PIPERAZINE

Base Information

• Chemical Name: 1,4-DI(2-PYRIDYL)PIPERAZINE
• CAS No.: 64728-49-0
• Molecular Formula: C14H16 N4
• Molecular Weight: 240.308
• Hs Code.: 2933990090
• Mol file: 64728-49-0.mol

Synonyms:NSC 19483;NSC 28698

Chemical Property of 1,4-DI(2-PYRIDYL)PIPERAZINE

Chemical Property:

• Melting Point: 127 °C
• Boiling Point: 435oC at 760 mmHg
• Flash Point: 216.9oC
• PSA: 32.26000
• Density: 1.181g/cm3
• LogP: 1.93320

Purity/Quality:

99% ^*data from raw suppliers

1,4-Di(2-pyridyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-DI(2-PYRIDYL)PIPERAZINE

There total 5 articles about 1,4-DI(2-PYRIDYL)PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

piperazine (110-85-0) + 2-chloropyridine (109-09-1) → 1,4-bis-(2-pyridyl)-1,4-diazacyclohexane (64728-49-0)

Guidance literature:

at 140 ℃; for 4h;

DOI:10.1055/s-2006-939714

Reference yield: 87.0%

piperazine (110-85-0) + 2-fluoropyridine (372-48-5) → 1,4-bis-(2-pyridyl)-1,4-diazacyclohexane (64728-49-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 100 ℃; for 96h; under 6000480 Torr;

DOI:10.3987/COM-94-6952

Reference yield: 78.0%

piperazine (110-85-0) + 2-chloropyridine (109-09-1) → 1-(2-pyridyl)piperazine (34803-66-2) + 1,4-bis-(2-pyridyl)-1,4-diazacyclohexane (64728-49-0)

Guidance literature:

piperazine; With [2,2]bipyridinyl; nickel diacetate; sodium hydride; tert-Amyl alcohol; In tetrahydrofuran; at 65 ℃; for 2h;

2-chloropyridine; With styrene; In tetrahydrofuran; at 65 ℃; for 7h;

DOI:10.1016/S0040-4020(02)00750-0

upstream raw materials:

piperazine

2-bromo-pyridine

2-fluoropyridine

2-chloropyridine

Refernces

• 1、 Matsumoto, Kiyoshi,Fukuyama, Keisuke,Iida, Hirokazu,Toda, Mitsuo,Lown, J. William. "SYNTHESIS OF NEW ARMED CYCLOPOLYAMINES AND THEIR SELECTIVE EXTRACTION PROPERTIES FOR METAL IONS". . p. 237 - 244. Retrieved 1995.
• 2、 Brenner, Eric,Schneider, Rapha?l,Fort, Yves. "Nickel-catalysed selective N-arylation or N,N′-diarylation of secondary diamines". . p. 6913 - 6924. Retrieved 2007/10/03.