6,7-dichloro-3-(4-fluorophenyl)quinoxaline-2-carbaldehyde

Base Information

• Chemical Name: 6,7-dichloro-3-(4-fluorophenyl)quinoxaline-2-carbaldehyde
• CAS No.: 1420295-86-8
• Molecular Formula: C₁₅H₇Cl₂FN₂O
• Molecular Weight: 321.138
• Mol file: 1420295-86-8.mol

Synonyms:6,7-dichloro-3-(4-fluorophenyl)quinoxaline-2-carbaldehyde

Chemical Property of 6,7-dichloro-3-(4-fluorophenyl)quinoxaline-2-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 6,7-dichloro-3-(4-fluorophenyl)quinoxaline-2-carbaldehyde

There total 3 articles about 6,7-dichloro-3-(4-fluorophenyl)quinoxaline-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

6,7-dichloro-2-(dimethoxymethyl)-3-(4-fluorophenyl)quinoxaline (1420295-70-0) → 6,7-dichloro-3-(4-fluorophenyl)quinoxaline-2-carbaldehyde (1420295-86-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 70 ℃; for 6h;

DOI:10.1021/jo302450f

Reference yield: 82.0%

6,7-Dichloro-2-(4-fluorophenyl)-3-methylquinoxaline (1572247-69-8) → 6,7-dichloro-3-(4-fluorophenyl)quinoxaline-2-carbaldehyde (1420295-86-8)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; for 3h; Reflux;

DOI:10.3390/ijms20194786

Reference yield:

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) → 6,7-dichloro-3-(4-fluorophenyl)quinoxaline-2-carbaldehyde (1420295-86-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; water / 3 h / Reflux

2: selenium(IV) oxide / 1,4-dioxane / 3 h / Reflux

With selenium(IV) oxide; In 1,4-dioxane; ethanol; water;

DOI:10.3390/ijms20194786

upstream raw materials:

6,7-dichloro-2-(dimethoxymethyl)-3-(4-fluorophenyl)quinoxaline

6,7-Dichloro-2-(4-fluorophenyl)-3-methylquinoxaline

4,5-Dichloro-1,2-phenylenediamine