1-benzyl-5-chloro-1H-indole-3-carbonitrile

Base Information

Chemical Name:1-benzyl-5-chloro-1H-indole-3-carbonitrile
CAS No.:1426847-72-4
Molecular Formula:C₁₆H₁₁ClN₂
Molecular Weight:266.73
Hs Code.:

Synonyms:1-benzyl-5-chloro-1H-indole-3-carbonitrile

Suppliers and Price of 1-benzyl-5-chloro-1H-indole-3-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 1-benzyl-5-chloro-1H-indole-3-carbonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 1-benzyl-5-chloro-1H-indole-3-carbonitrile

There total 3 articles about 1-benzyl-5-chloro-1H-indole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 75-05-8,26809-02-9
acetonitrile

: 92433-38-0
1-benzyl-5-chloro-1H-indole

: 1426847-72-4
1-benzyl-5-chloro-1H-indole-3-carbonitrile

Guidance literature:: With oxygen; copper diacetate; silver trifluoromethanesulfonate; palladium dichloride; 4-nitro-benzoic acid; In N,N-dimethyl-formamide; at 135 ℃; for 36h; under 760.051 Torr; Schlenk technique; Green chemistry;
DOI:10.1039/d0ob00485e

Reference yield: 73.0%

: 140-29-4
phenylacetonitrile

: 92433-38-0
1-benzyl-5-chloro-1H-indole

: 1426847-72-4
1-benzyl-5-chloro-1H-indole-3-carbonitrile

Guidance literature:: With copper(l) iodide; In N,N-dimethyl-formamide; for 28h; regioselective reaction;
DOI:10.1021/jo3028278

Reference yield:

: 17422-32-1
5-chloro-1H-indole

: 100-39-0
benzyl bromide

: 1426847-72-4
1-benzyl-5-chloro-1H-indole-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: palladium dichloride; copper diacetate; 4-nitro-benzoic acid; oxygen; silver trifluoromethanesulfonate / N,N-dimethyl-formamide / 36 h / 135 °C / 760.05 Torr / Schlenk technique; Green chemistry

With oxygen; copper diacetate; silver trifluoromethanesulfonate; potassium hydroxide; palladium dichloride; 4-nitro-benzoic acid; In N,N-dimethyl-formamide;
DOI:10.1039/d0ob00485e